重组人NRG1蛋白

产品详情

  • 产品名称
    重组人NRG1蛋白
  • 蛋白种属
  • 表达宿主
    人胚胎肾细胞(HEK293)
  • Unitprot ID
  • 克隆构建
    A DNA sequence encoding the N-terminal fragment (Ser 2-Lys 246) of human NRG1 isoform beta1 (Q02297-6) was expressed, fused with the Fc region of mouse IgG1 at the N-terminus.
  • 蛋白纯度
    > 88 % as determined by SDS-PAGE
  • 蛋白活性
    1. Measured by its ability to bind with human ErbB4-His (Cat:503994) in a functional ELISA.
    2. Measured by its ability to bind with human ErbB3-His (Cat:503568) in a functional ELISA.
  • 分子量
    The recombinant human NRG1/mFc is a disulfide-linked homodimer. The reduced monomer comprises 481 amino acids and has a predicted molecular mass of 53.4 kDa. The apparent molecular mass of the monomer is approximately 67 kDa in SDS-PAGE under reducing conditions due to glycosylation.
  • 蛋白别名
    6030402G23RIK; GGF2; D230005F13RIK; HRGALPHA; HRGA; ARIA; HGL; NDF; HRG; NRG1-IT2; GGFII; SMDF; MST131; GGF; MSTP131; HRG1
  • 蛋白全名
    Pro-neuregulin-1, membrane-bound isoform
  • 蛋白描述
    Neuregulin 1 or NRG1 is one of four proteins in the neuregulin family that act on the EGFR family of receptors. This growth factor was originally identified as a 44-kD glycoprotein that interacts with the NEU / ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues. NRG1 is a trophic factor that has been implicated in neural development, neurotransmission, and synaptic plasticity. NRG1 has multiple isoforms that are generated by usage of different promoters and alternative splicing of a single gene. Neuregulin 1 (NRG1) is essential for the development and function of multiple organ systems, and its dysregulation has been linked to diseases such as cancer and schizophrenia. NRG1 is a schizophrenia candidate gene and plays an important role in brain development and neural function. Schizophrenia is a complex disorder, with etiology likely due to epistasis. 
  • 发货形式
    Lyophilized from sterile PBS, pH 7.4
    1. 5 % trehalose and mannitol are added as protectants before lyophilization.
    2. Please contact us for any concerns or special requirements.
  • 内毒素
    < 1.0 EU per μg of the protein as determined by the LAL method
  • 保存条件
    Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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