重组人VAPB蛋白

人

大肠杆菌

A DNA sequence encoding the Human VAPB/UNQ484/PRO983 Ala2-Pro132 is expressed with a 6His tag at the C-terminus.

>95% as determined by SDS-PAGE.

UNQ484; PRO983

VAMP associated protein B and C(VAPB)

vesicle-associated membrane protein-associated protein B/C (VAPB) is presents in mitochondria-associated membranes that are endoplasmic reticulum membrane regions closely apposed to the outer mitochondrial membrane. It can form homodimer, and heterodimer with VAPA. It also interacts with VAMP1, VAMP2, HCV NS5A, NS5B, ZFYVE27 and RMDN3. VAPB participates in the endoplasmic reticulum unfolded protein response (UPR) by inducing ERN1/IRE1 activity. It is involved in cellular calcium homeostasis regulation.

Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4.

<1.0 EU per μg protein as determined by the LAL method.

Lyophilized protein should be stored at <-20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-7 days.