- 抗体类型:多克隆
- 抗体来源:兔
- 抗体应用:ELISA, WB, IHC
- 特异性:Human,Mouse,Rat; other species not tested.
产品详情
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产品名称
IL13RA2 antibody
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抗体类型
多克隆
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抗体来源
兔
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抗体亚型
兔IgG
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抗体描述
IL13RA2 Rabbit Polyclonal antibody. Positive IHC detected in human breast cancer tissue, human brain tissue, human gliomas tissue, human ovary tumor tissue. Positive WB detected in rat thymus tissue, HeLa cells, rat liver tissue. Observed molecular weight by Western-blot: 65 kDa
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抗体应用
ELISA, WB, IHC
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应用推荐
Recommended Dilution:
WB: 1:200-1:1000
IHC: 1:50-1:500
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特异性
Human,Mouse,Rat; other species not tested.
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蛋白别名
CD213A2, CT19, IL 13 receptor subunit alpha 2, IL 13R, IL 13R alpha 2, IL 13R subunit alpha 2, IL 13RA2, IL13BP, IL13R, IL13RA2, IL13Ralpha2, Interleukin 13 binding protein
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制备方法
This antibody was obtained by immunization of IL13RA2 recombinant protein (Accession Number: NM_000640). Purification method: Antigen affinity purified.
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组分
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
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储存方法
Store at -20℃. DO NOT ALIQUOT
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背景介绍
IL13RA2, also named as IL13R and CD213a2, belongs to the type I cytokine receptor family. It binds as a monomer with high affinity to interleukin-13 (IL13), but not to interleukin-4 (IL4). IL13RA2 lacks the cytoplasmic domain for signaling, indicating that it acts as a decoy receptor. IL13RA2 gene polymorphisms have been associated with systemic sclerosis (PMID: 16981293). Overexpression of IL13RA2 gene has been reported in several types of cancer, including melanoma, lung cancer, and brain tumor, which makes it a potential immunotherapeutic target (PMID: 19895199; 24970476; 24021875).
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参考文献
- Akiyama Y, Komiyama M, Miyata H. Novel cancer-testis antigen expression on glioma cell lines derived from high-grade glioma patients. Oncology reports. 31(4):1683-90. 2014.
- Brøchner CB, Holst CB, Møllgård K. Outer brain barriers in rat and human development. Frontiers in neuroscience. 9:75. 2015.