- 抗体类型:多克隆
- 抗体来源:兔
- 抗体应用:ELISA, IHC, WB
- 特异性:Human, Mouse; other species not tested.
产品详情
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产品名称
ING3 antibody
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抗体类型
多克隆
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抗体来源
兔
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抗体亚型
兔IgG
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抗体描述
ING3 Rabbit Polyclonal antibody. Positive IHC detected in human breast cancer tissue. Positive WB detected in mouse uterus tissue, HepG2 cells. Observed molecular weight by Western-blot: 47 kDa
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抗体应用
ELISA, IHC, WB
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应用推荐
Recommended Dilution:
WB: 1:200-1:2000
IHC: 1:20-1:200
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特异性
Human, Mouse; other species not tested.
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蛋白别名
Eaf4, FLJ20089, ING2, ING3, Inhibitor of growth protein 3, p47ING3
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制备方法
This antibody was obtained by immunization of ING3 recombinant protein (Accession Number: NM_198267). Purification method: Antigen affinity purified.
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组分
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
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储存方法
Store at -20℃. DO NOT ALIQUOT
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背景介绍
Members of inhibitor of growth (ING) family function in inhibiting cell growth and inducing apoptosis. They are sequence homologous proteins. ING3 can activate p53 trans-activated promoters, including promoters of p21/waf1 and bax. This antibody is specifically against p47ING3.
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参考文献
- Chen G, Wang Y, Garate M, Zhou J, Li G. The tumor suppressor ING3 is degraded by SCF(Skp2)-mediated ubiquitin-proteasome system. Oncogene. 29(10):1498-508. 2010.
- Jin L, Li D, Lee JS. p90 RSK2 mediates antianoikis signals by both transcription-dependent and -independent mechanisms. Molecular and cellular biology. 33(13):2574-85. 2013.
- Gou WF, Sun HZ, Zhao S. Downregulated inhibitor of growth 3 (ING3) expression during colorectal carcinogenesis. The Indian journal of medical research. 139(4):561-7. 2014.
- Yu G, Lee YC, Cheng CJ. RSK promotes prostate cancer progression in bone through ING3, CKAP2, and PTK6-mediated cell survival. Molecular cancer research : MCR. 13(2):348-57. 2015.
- Wang Y, Dai DL, Martinka M, Li G. Prognostic significance of nuclear ING3 expression in human cutaneous melanoma. Clinical cancer research : an official journal of the American Association for Cancer Research. 13(14):4111-6. 2007.