- 抗体类型:多克隆
- 抗体来源:兔
- 抗体应用:ELISA, WB, IHC, FC
- 特异性:Human; other species not tested.
产品详情
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产品名称
Integrin alpha-1 antibody
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抗体类型
多克隆
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抗体来源
兔
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抗体亚型
兔IgG
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抗体描述
Integrin alpha-1 Rabbit Polyclonal antibody. Positive IHC detected in human tonsillitis tissue. Positive FC detected in HeLa cells. Positive WB detected in HepG2 cells, SMMC-7721 cells. Observed molecular weight by Western-blot: 180 kDa
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抗体应用
ELISA, WB, IHC, FC
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应用推荐
Recommended Dilution:
WB: 1:500-1:5000
IHC: 1:20-1:200
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特异性
Human; other species not tested.
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蛋白别名
CD49a, Integrin alpha 1, integrin, alpha 1, ITGA1, Laminin and collagen receptor, VLA 1, VLA1
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制备方法
This antibody was obtained by immunization of Integrin alpha-1 recombinant protein (Accession Number: NM_181501). Purification method: Antigen Affinity purified.
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组分
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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储存方法
Store at -20℃. DO NOT ALIQUOT
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背景介绍
The integrins are a superfamily of cell adhesion receptors that bind to extracellular matrix ligands, cell-surface ligands, and soluble ligands (PMID: 17543136). They are transmembrane αβ heterodimers and at least 24 distinct integrin heterodimers are formed by the combination of 18 α and eight β known subunits (PMID: 17543136; 20029421). In addition to mediating cell adhesion, integrins also play important roles in modulating signal transduction pathways that control cellular responses including migration, proliferation, differentiation, and apoptosis (PMID:19118207). Integrin alpha-1 (ITGA1, CD49a) combines with the beta 1 subunit (ITGB1, CD29) to form a cell-surface receptor for collagen and laminin. This receptor is involved in cell-cell adhesion and may play a role in inflammation and fibrosis.