- 抗体类型:多克隆
- 抗体来源:兔
- 抗体应用:WB
- 特异性:Human, Mouse
IPO11 Polyclonal Antibody
产品详情
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产品名称
IPO11 Polyclonal Antibody
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抗体类型
多克隆
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抗体来源
兔
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抗体亚型
兔IgG
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抗体描述
Polyclonal antibody to IPO11
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抗体应用
WB
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应用推荐
WB 1:500 - 1:2000
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特异性
Human, Mouse
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蛋白别名
IPO11, RanBP11, importin-11
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制备方法
Antigen: Recombinant fusion protein containing a sequence corresponding to amino acids 776-975 of human IPO11 (NP_057422.3).
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组分
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
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储存方法
Store at -20℃. Avoid freeze / thaw cycles.
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背景介绍
Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of UBE2E3, and of RPL12 (By similarity).
相关服务
抗体定制服务: 纽普生物（NovoPro）提供单克隆抗体及多克隆抗体定制服务