重组人KLK6蛋白

产品详情

  • 产品名称
    重组人KLK6蛋白
  • 蛋白种属
  • 表达宿主
    人胚胎肾细胞(HEK293)
  • Unitprot ID
  • 克隆构建
    A DNA sequence encoding the human KLK6 (NP_002765.1) (Met1-Lys244) was expressed with six amino acids (LEVLFQ) at the C- terminus.
  • 蛋白纯度
    > (61.6 +34.0) % as determined by SDS-PAGE.
  • 分子量
    The recombinant human KLK6 consists 235 amino acids and predicts a molecular mass of 25.9 kDa.
  • 蛋白别名
    MSP; KLK29; KALLIKREIN 29; KLK7; AI849898; SERINE PROTEASE 9; PROTEASE; BRAIN SERINE PROTEASE; SP59; KALLIKREIN-6; SERINE; PRSS9; BSSP; HK6; BSP; SERINE PROTEASE 18; MYELENCEPHALON-SPECIFIC PROTEASE; KALLIKREIN 6; NEUROSIN; ZYME; MYOFIBRIL-BOUND PROTEASE; PROTEASE M; PRSS18
  • 蛋白全名
    Kallikrein 6 (Neurosin, zyme), isoform CRA_b
  • 蛋白描述
    KLK6 (kallikrein-related peptidase 6), also known as Klk7, belongs to the peptidase S1 family, Kallikrein subfamily. Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. KLK6 is a serine protease which exhibits a preference for Arg over Lys in the substrate P1 position and for Ser or Pro in the P2 position. Klk7 shows activity against amyloid precursor protein, myelin basic protein, gelatin, casein and extracellular matrix proteins such as fibronectin, laminin, vitronectin and collagen. KLK6 degrades alpha-synuclein and prevents its polymerization, indicating that KLK6 may be involved in the pathogenesis of Parkinson disease and other synucleinopathies. Klk7 may be involved in regulation of axon outgrowth following spinal cord injury. Tumor cells treated with a neutralizing KLK6 antibody migrate less than control cells, suggesting a role in invasion and metastasis.
  • 发货形式
    Lyophilized from sterile PBS, pH 7.4.
    1. 5 % trehalose and mannitol are added as protectants before lyophilization.
    2. Please contact us for any concerns or special requirements.
  • 内毒素
    <1.0 EU per μg protein as determined by the LAL method.
  • 保存条件
    Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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