LC3 antibody

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  • 抗体类型:多克隆
  • 抗体来源:兔
  • 抗体应用:ELISA, IF, WB
  • 特异性:Human,Mouse,Rat,Zebrafish; other species not tested.

产品详情

  • 产品名称
    LC3 antibody
  • 抗体类型
    多克隆
  • 抗体来源
    兔
  • 抗体亚型
    兔IgG
  • 抗体描述
    LC3 Rabbit Polyclonal antibody. Positive IF detected in Starvation treated HEK-293 cells. Positive WB detected in Chloroquine treated HeLa cells, Chloroquine treated HEK-293 cells, human brain tissue, mouse brain tissue, rat brain tissue. Observed molecular weight by Western-blot: 16 kDa
  • 抗体应用
    ELISA, IF, WB
  • 应用推荐

    Recommended Dilution:

    WB: 1:500-1:5000

    IF: 1:20-1:200

  • 特异性
    Human,Mouse,Rat,Zebrafish; other species not tested.
  • 蛋白别名
    LC3, LC3A, LC3A/B, MAP1A/MAP1B LC3 A, MAP1A/MAP1B light chain 3 A, MAP1ALC3, MAP1BLC3, MAP1LC3A
  • 制备方法
    This antibody was obtained by immunization of LC3 recombinant protein (Accession Number: XM_047440559). Purification method: Antigen affinity purified.
  • 组分
    PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
  • 储存方法
    Store at -20℃. DO NOT ALIQUOT
  • 背景介绍
    LC3, also known as microtubule-associated protein 1 light chain 3 (MAP1LC3), is a mammalian homolog of the yeast Atg8p (autophagy-related 8 protein) that is involved in autophagy process. Three isoforms of LC3 exist as LC3A,LC3B, and LC3C. LC3 is first synthesized as pro-LC3, and undergoes C-terminal cleavage to yield a cytosolic precursor known as LC3-I. During autophagy LC3-I is subsequently conjugated to PE lipid as lipidated form: LC3-II. The lipidated form migrates faster on SDS-PAGE gel. The increased the level of LC3-II has been widely used as autophagy marker. This antibody recognizes both LC3-I and LC3-II.
  • 参考文献
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