- 抗体类型:多克隆
- 抗体来源:兔
- 抗体应用:ELISA, WB, IHC, IP, IF
- 特异性:Human,Mouse,Rat; other species not tested.
产品详情
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产品名称
LONP1 antibody
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抗体类型
多克隆
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抗体来源
兔
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抗体亚型
兔IgG
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抗体描述
LONP1 Rabbit Polyclonal antibody. Positive IP detected in mouse heart tissue. Positive WB detected in HeLa cells, HepG2 cells, human heart tissue, mouse heart tissue, rat heart tissue, rat lung tissue. Positive IF detected in HepG2 cells. Positive IHC detected in human lung cancer tissue. Observed molecular weight by Western-blot: 100 kDa
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抗体应用
ELISA, WB, IHC, IP, IF
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应用推荐
Recommended Dilution:
WB: 1:200-1:2000
IP: 1:500-1:5000
IHC: 1:20-1:200
IF: 1:10-1:100
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特异性
Human,Mouse,Rat; other species not tested.
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蛋白别名
hLON, LON, lon peptidase 1, mitOChondrial, Lon protease like protein, LonHS, LONP, LONP1, PIM1, PRSS15, Serine protease 15
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制备方法
This antibody was obtained by immunization of LONP1 recombinant protein (Accession Number: NM_004793). Purification method: Antigen affinity purified.
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组分
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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储存方法
Store at -20℃. DO NOT ALIQUOT
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背景介绍
LONP1(Lon protease homolog, mitochondrial) is also named as LONP, LONHS, HLON, LON, PRSS15, PIM1, MGC1498 and belongs to the peptidase S16 family. It seems to play a major role in the elimination of oxidatively modified proteins in the mitochondrial matrix(PMID:18021745). LONP1, also a nuclearly encoded and mitochondrially located stress-responsive protease, is involved in heme-mediated ALAS-1 turnover(PMID:21659532). It recognizes specific surface determinants or folds, initiates proteolysis at solvent-accessible sites, and generates unfolded polypeptides that are then processively degraded(PMID:15870080).
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参考文献
- Kil IS, Ryu KW, Lee SK. Circadian Oscillation of Sulfiredoxin in the Mitochondria. Molecular cell. 59(4):651-63. 2015.
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- Moore F, Santin I, Nogueira TC. The transcription factor C/EBP delta has anti-apoptotic and anti-inflammatory roles in pancreatic beta cells. PloS one. 7(2):e31062. 2012.
- Cnop M, Abdulkarim B, Bottu G. RNA sequencing identifies dysregulation of the human pancreatic islet transcriptome by the saturated fatty acid palmitate. Diabetes. 63(6):1978-93. 2014.
- Shen XL, Zhang B, Liang R. Central role of Nix in the autophagic response to ochratoxin A. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 69:202-9. 2014.