LRDD antibody

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  • 抗体类型:多克隆
  • 抗体来源:
  • 抗体应用:ELISA, IF, IP, WB, IHC
  • 特异性:Human,Mouse,Rat; other species not tested.


  • 产品名称
    LRDD antibody
  • 抗体类型
  • 抗体来源
  • 抗体亚型
  • 抗体描述
    LRDD Rabbit Polyclonal antibody. Positive IHC detected in human pancreas tissue, human liver tissue. Positive IF detected in Hela cells. Positive IP detected in L02 cells. Positive WB detected in L02 cells, HEK-293 cells. Observed molecular weight by Western-blot: 55 kDa
  • 抗体应用
  • 应用推荐

    Recommended Dilution:

    WB: 1:200-1:1000

    IP: 1:200-1:2000

    IHC: 1:20-1:200

    IF: 1:10-1:100

  • 特异性
    Human,Mouse,Rat; other species not tested.
  • 蛋白别名
    DKFZp434D229, LRDD, PIDD
  • 制备方法
    This antibody was obtained by immunization of LRDD recombinant protein (Accession Number: NM_145887). Purification method: Antigen affinity purified.
  • 组分
    PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
  • 储存方法
    Store at -20℃. DO NOT ALIQUOT
  • 背景介绍
    P53-induced protein with a death domain (PIDD/LRDD) is a component of the PIDDosome. PIDD contains 910 residues with 7 leucine rich repeats (LRRs), 2 ZU-5 domains and a C-terminal death domain (DD). PIDD can be cleaved into shorter fragments generating a PIDD-N fragment of 48 kD (residues 1-446), a PIDD-C fragment of 51 kD (residues 447-910) and a PIDD-CC fragment of 37 kD (residues 589-910). Auto-cleavage of PIDD determines the downstream signaling events. The PIDD-C fragment mediates activation of NFκB via the recruitment of RIP1 and NEMO, while PIDD-CC causes caspase-2 activation, which leads to apoptosis.

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