MAPK7 Polyclonal Antibody

0 条评论 | 添加你的评论
  • 抗体类型:多克隆
  • 抗体来源:兔
  • 抗体应用:WB, IF
  • 特异性:Human, Mouse, Rat

产品详情

  • 产品名称
    MAPK7 Polyclonal Antibody
  • 抗体类型
    多克隆
  • 抗体来源
    兔
  • 抗体亚型
    兔IgG
  • 抗体描述
    Polyclonal antibody to MAPK7
  • 抗体应用
    WB, IF
  • 应用推荐
    WB 1:500 - 1:2000
    IF 1:50 - 1:200
  • 特异性
    Human, Mouse, Rat
  • 蛋白别名
    MAPK7, BMK1, ERK4, ERK5, PRKM7, mitogen-activated protein kinase 7
  • 制备方法
    Antigen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-310 of human MAPK7 (NP_002740.2).
  • 组分
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 储存方法
    Store at -20℃. Avoid freeze / thaw cycles.
  • 背景介绍
    Plays a role in various cellular processes such as proliferation, differentiation and cell survival. The upstream activator of MAPK7 is the MAPK kinase MAP2K5. Upon activation, it translocates to the nucleus and phosphorylates various downstream targets including MEF2C. EGF activates MAPK7 through a Ras-independent and MAP2K5-dependent pathway. May have a role in muscle cell differentiation. May be important for endothelial function and maintenance of blood vessel integrity. MAP2K5 and MAPK7 interact specifically with one another and not with MEK1/ERK1 or MEK2/ERK2 pathways. Phosphorylates SGK1 at Ser-78 and this is required for growth factor-induced cell cycle progression. Involved in the regulation of p53/TP53 by disrupting the PML-MDM2 interaction.
声明：本公司出售产品只能用于科研目的，不得用于诊断或者治疗！