- 抗体类型:多克隆
- 抗体来源:兔
- 抗体应用:ELISA, WB, IP
- 特异性:Human; other species not tested.
产品详情
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产品名称
ME2 antibody
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抗体类型
多克隆
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抗体来源
兔
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抗体亚型
兔IgG
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抗体描述
ME2 Rabbit Polyclonal antibody. Positive IP detected in HeLa cells. Positive WB detected in K-562 cells, HeLa cells, HL-60 cells, Jurkat cells. Observed molecular weight by Western-blot: 54 kDa, 65 kDa
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抗体应用
ELISA, WB, IP
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应用推荐
Recommended Dilution:
WB: 1:200-1:2000
IP: 1:200-1:2000
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特异性
Human; other species not tested.
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蛋白别名
Malic enzyme 2, ME2, NAD ME
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制备方法
This antibody was obtained by immunization of ME2 recombinant protein (Accession Number: NM_001168335). Purification method: Antigen affinity purified.
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组分
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
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储存方法
Store at -20℃. DO NOT ALIQUOT
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背景介绍
ME2(malic enzyme 2) is also named as NAD-ME and belongs to the malic enzymes family. ME1, ME2 are important for NADPH production, lipogenesis and glutamine metabolism, but ME2 has a more profound effect. ME2 is a genome-coded mitochondrial enzyme that converts malate to pyruvate and is involved in neuronal synthesis of the neurotransmitter γ-aminobutyric acid (GABA)(PMID:15532013). This protein has 2 isoforms produced by alternative splicing with the MW of 65 kDa and 54 kDa.
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参考文献
- Sun L, Song L, Wan Q. cMyc-mediated activation of serine biosynthesis pathway is critical for cancer progression under nutrient deprivation conditions. Cell research. 25(4):429-44. 2015.