重组小鼠Slamf1蛋白

产品详情

  • 产品名称
    重组小鼠Slamf1蛋白
  • 蛋白种属
    小鼠
  • 表达宿主
    人胚胎肾细胞(HEK293)
  • Unitprot ID
  • 克隆构建
    A DNA sequence encoding the Mouse Slamf1/Slam Thr25-Pro242 is expressed with a 6His tag at the C-terminus.
  • 蛋白纯度
    >95% as determined by SDS-PAGE.
  • 蛋白别名
    Slam
  • 蛋白全名
    signaling lymphocytic activation molecule family member 1(Slamf1)
  • 蛋白描述
    Signaling lymphocyte activation molecule (SLAM), is a self-ligand glycoprotein which exists not only found on the surface of activated and memory T cells, but also on the surface of activated B cells, dendritic cells, and macrophages. SLAM consists of a extracellular domain (ECD) with two Ig-like domains,transmembrane segment, and cytoplasmic domain with three immunoreceptor tyrosine switch motifs (ITSM). SLAM is thought to play an important role in adhesion between T cells and APCs and has been shown to act as a coreceptor in TCR-dependent responses. SLAM, together with CD46, is one of the two receptors for measles virus. SLAM is a cell surface receptor that, like the B cell receptor, CD40, and CD95, can transmit positive or negative signals. SLAM can associate with the SH2-containing inositol phosphatase (SHIP), the SH2-containing protein tyrosine phosphatase (SHP-2), and the adaptor protein SH2 domain protein 1A. It’s upregulated on activated B cells and CD4+ and CD8+ T cells, but downregulated on Th2 polarized cells. Also, it can Inhibits antigen receptor-mediated production of IFN-gamma, but not IL-2, in CD4-/CD8- T-cells
  • 发货形式
    Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4.
  • 内毒素
    <1.0 EU per μg protein as determined by the LAL method.
  • 保存条件
    Lyophilized protein should be stored at <-20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
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