重组小鼠Slamf1蛋白
- 蛋白种属:小鼠
- 表达宿主:人胚胎肾细胞(HEK293)
- Unitprot ID:Q9QUM4
产品详情
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产品名称
重组小鼠Slamf1蛋白
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蛋白种属
小鼠
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表达宿主
人胚胎肾细胞(HEK293)
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Unitprot ID
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克隆构建
A DNA sequence encoding the Mouse Slamf1/Slam Thr25-Pro242 is expressed with a 6His tag at the C-terminus.
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蛋白纯度
>95% as determined by SDS-PAGE.
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蛋白别名
Slam
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蛋白全名
signaling lymphocytic activation molecule family member 1(Slamf1)
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蛋白描述
Signaling lymphocyte activation molecule (SLAM), is a self-ligand glycoprotein which exists not only found on the surface of activated and memory T cells, but also on the surface of activated B cells, dendritic cells, and macrophages. SLAM consists of a extracellular domain (ECD) with two Ig-like domains,transmembrane segment, and cytoplasmic domain with three immunoreceptor tyrosine switch motifs (ITSM). SLAM is thought to play an important role in adhesion between T cells and APCs and has been shown to act as a coreceptor in TCR-dependent responses. SLAM, together with CD46, is one of the two receptors for measles virus. SLAM is a cell surface receptor that, like the B cell receptor, CD40, and CD95, can transmit positive or negative signals. SLAM can associate with the SH2-containing inositol phosphatase (SHIP), the SH2-containing protein tyrosine phosphatase (SHP-2), and the adaptor protein SH2 domain protein 1A. It’s upregulated on activated B cells and CD4+ and CD8+ T cells, but downregulated on Th2 polarized cells. Also, it can Inhibits antigen receptor-mediated production of IFN-gamma, but not IL-2, in CD4-/CD8- T-cells
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发货形式
Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4.
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内毒素
<1.0 EU per μg protein as determined by the LAL method.
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保存条件
Lyophilized protein should be stored at <-20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
重组蛋白定制服务:
纽普生物(NovoPro)提供大肠杆菌、哺乳细胞、昆虫细胞和酵母细胞重组蛋白定制服务
声明:本公司出售产品只能用于科研目的,不得用于诊断或者治疗!