重组小鼠Vtcn1蛋白

产品详情

  • 产品名称
    重组小鼠Vtcn1蛋白
  • 蛋白种属
    小鼠
  • 表达宿主
    人胚胎肾细胞(HEK293)
  • Unitprot ID
  • 克隆构建
    A DNA sequence encoding the Mouse Vtcn1/B7h4 Leu25-Ser256 is expressed with a Fc tag at the C-terminus.
  • 蛋白纯度
    >95% as determined by SDS-PAGE.
  • 蛋白别名
    B7h4
  • 蛋白全名
    V-set domain containing T cell activation inhibitor 1(Vtcn1)
  • 蛋白描述
    Mouse V-set domain-containing T-cell activation inhibitor 1/VTCN1/B7-H4 is glycosylated member of the B7 family of immune co‑stimulatory proteins. B7-H4 consists of extracellular domain (ECD) with one Ig-like V-set domain and one Ig-like C2-set domain. It is widely expressed, including in kidney, liver, lung, pancreas, placenta, prostate, spleen, testis and thymus. B7-H4 negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor-associated antigen-specific T-cell immunity. It also involved in promoting epithelial cell transformation.
  • 发货形式
    Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
  • 内毒素
    <1.0 EU per μg protein as determined by the LAL method.
  • 保存条件
    Lyophilized protein should be stored at <-20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
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