重组小鼠Vtcn1蛋白
- 蛋白种属:小鼠
- 表达宿主:人胚胎肾细胞(HEK293)
- Unitprot ID:Q7TSP5
产品详情
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产品名称
重组小鼠Vtcn1蛋白
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蛋白种属
小鼠
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表达宿主
人胚胎肾细胞(HEK293)
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Unitprot ID
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克隆构建
A DNA sequence encoding the Mouse Vtcn1/B7h4 Leu25-Ser256 is expressed with a Fc tag at the C-terminus.
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蛋白纯度
>95% as determined by SDS-PAGE.
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蛋白别名
B7h4
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蛋白全名
V-set domain containing T cell activation inhibitor 1(Vtcn1)
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蛋白描述
Mouse V-set domain-containing T-cell activation inhibitor 1/VTCN1/B7-H4 is glycosylated member of the B7 family of immune co‑stimulatory proteins. B7-H4 consists of extracellular domain (ECD) with one Ig-like V-set domain and one Ig-like C2-set domain. It is widely expressed, including in kidney, liver, lung, pancreas, placenta, prostate, spleen, testis and thymus. B7-H4 negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor-associated antigen-specific T-cell immunity. It also involved in promoting epithelial cell transformation.
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发货形式
Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
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内毒素
<1.0 EU per μg protein as determined by the LAL method.
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保存条件
Lyophilized protein should be stored at <-20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
重组蛋白定制服务:
纽普生物(NovoPro)提供大肠杆菌、哺乳细胞、昆虫细胞和酵母细胞重组蛋白定制服务
声明:本公司出售产品只能用于科研目的,不得用于诊断或者治疗!