- Unitprot ID:Q7TSP5
A DNA sequence encoding the Mouse Vtcn1/B7h4 Leu25-Ser256 is expressed with a Fc tag at the C-terminus.
>95% as determined by SDS-PAGE.
V-set domain containing T cell activation inhibitor 1(Vtcn1)
Mouse V-set domain-containing T-cell activation inhibitor 1/VTCN1/B7-H4 is glycosylated member of the B7 family of immune co‑stimulatory proteins. B7-H4 consists of extracellular domain (ECD) with one Ig-like V-set domain and one Ig-like C2-set domain. It is widely expressed, including in kidney, liver, lung, pancreas, placenta, prostate, spleen, testis and thymus. B7-H4 negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor-associated antigen-specific T-cell immunity. It also involved in promoting epithelial cell transformation.
Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
<1.0 EU per μg protein as determined by the LAL method.
Lyophilized protein should be stored at <-20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-7 days.