- 抗体类型:多克隆
- 抗体来源:兔
- 抗体应用:ELISA, WB, IP
- 特异性:Human,Mouse,Rat; other species not tested.
产品详情
-
产品名称
NKRF antibody
-
抗体类型
多克隆
-
抗体来源
兔
-
抗体亚型
兔IgG
-
抗体描述
NKRF Rabbit Polyclonal antibody. Positive IP detected in A549 cells. Positive WB detected in Jurkat cells, A431 cells, A549 cells, HepG2 cells, PC-3 cells. Observed molecular weight by Western-blot: 100 kDa
-
抗体应用
ELISA, WB, IP
-
应用推荐
Recommended Dilution:
WB: 1:1000-1:10000
IP: 1:500-1:5000
-
特异性
Human,Mouse,Rat; other species not tested.
-
蛋白别名
ITBA4, NF kappa B repressing factor, NKRF, NRF, Protein ITBA4, Transcription factor NRF
-
制备方法
This antibody was obtained by immunization of NKRF recombinant protein (Accession Number: NM_001173488). Purification method: Antigen affinity purified.
-
组分
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
-
储存方法
Store at -20℃. DO NOT ALIQUOT
-
背景介绍
NKRF, also named as Protein ITBA4 or Transcription factor NRF, is a 690 amino acid protein, which contains one G-patch domain and one R3H domain. NKRF is Widely and constitutively expressed, with lower level in colon, peripheral blood lymphocytes, lung and kidney. NKRF interacts with a specific negative regulatory element (NRE) 5'-AATTCCTCTGA-3' to mediate transcriptional repression of certain NK-kappa-B responsive genes. NKRF is involved in the constitutive silencing of the interferon beta promoter, independently of the virus-induced signals, and in the inhibition of the basal and cytokine-induced iNOS promoter activity.
-
参考文献
- Huang L, Liu Y, Wang L. Down-regulation of miR-301a suppresses pro-inflammatory cytokines in Toll-like receptor-triggered macrophages. Immunology. 140(3):314-22. 2013.