- 抗体类型:多克隆
- 抗体来源:兔
- 抗体应用:ELISA, WB, IHC, IF, IP
- 特异性:Human,Mouse,Rat; other species not tested.
产品详情
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产品名称
NXN antibody
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抗体类型
多克隆
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抗体来源
兔
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抗体亚型
兔IgG
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抗体描述
NXN Rabbit Polyclonal antibody. Positive WB detected in HeLa cells, human heart tissue. Positive IP detected in HeLa cells. Positive IF detected in HepG2 cells. Positive IHC detected in human testis tissue. Observed molecular weight by Western-blot: 48 kDa
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抗体应用
ELISA, WB, IHC, IF, IP
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应用推荐
Recommended Dilution:
WB: 1:200-1:2000
IP: 1:200-1:2000
IHC: 1:20-1:200
IF: 1:10-1:100
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特异性
Human,Mouse,Rat; other species not tested.
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蛋白别名
FLJ12614, NRX, nucleoredoxin, NXN, TRG 4
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制备方法
This antibody was obtained by immunization of NXN recombinant protein (Accession Number: NM_001205319). Purification method: Antigen affinity purified.
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组分
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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储存方法
Store at -20℃. DO NOT ALIQUOT
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背景介绍
Nucleoredoxin (NRX/NXN), a relatively uncharacterized member of the TRX family protein, has recently been reported to regulate the Wnt/β-catenin pathway, which itself regulates cell fate and early development, in a redox-dependent manner(PMID:17567240). Northern blot analysis detected several nucleoredoxin splice variants in adult mouse tissues, with highest expression in testis and skin and lowest expression in liver(PMID:9119370). It has 3 isoforms produced by alternative splicing. This antibody is specific to NXN.
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参考文献
- Kajla S, Mondol AS, Nagasawa A. A crucial role for Nox 1 in redox-dependent regulation of Wnt-β-catenin signaling. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 26(5):2049-59. 2012.
- Hamanaka RB, Glasauer A, Hoover P. Mitochondrial reactive oxygen species promote epidermal differentiation and hair follicle development. Science signaling. 6(261):ra8. 2013.