- 抗体类型:多克隆
- 抗体来源:兔
- 抗体应用:ELISA, WB, IP
- 特异性:Human; other species not tested.
产品详情
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产品名称
OIP5 antibody
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抗体类型
多克隆
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抗体来源
兔
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抗体亚型
兔IgG
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抗体描述
OIP5 Rabbit Polyclonal antibody. Positive IP detected in Jurkat cells. Positive WB detected in Jurkat cells, HeLa cells, PC-3 cells. Observed molecular weight by Western-blot: 25kd
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抗体应用
ELISA, WB, IP
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应用推荐
Recommended Dilution:
WB: 1:500-1:5000
IP: 1:200-1:2000
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特异性
Human; other species not tested.
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蛋白别名
5730547N13Rik, Cancer/testis antigen 86, CT86, LINT 25, MIS18B, MIS18beta, OIP 5, OIP5, Opa interacting protein 5, Protein Mis18 beta
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制备方法
This antibody was obtained by immunization of OIP5 recombinant protein (Accession Number: NM_007280). Purification method: Antigen affinity purified.
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组分
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
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储存方法
Store at -20℃. DO NOT ALIQUOT
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背景介绍
OIP5, also named as IS18B and CT86, is required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis. It is over expressed in the majority of primary lung and esophageal cancers. OIP5 is a promising target for developing new prognostic biomarkers and anti-cancer drugs.
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参考文献
- Wang J, Liu X, Dou Z. Mitotic regulator Mis18β interacts with and specifies the centromeric assembly of molecular chaperone holliday junction recognition protein (HJURP). The Journal of biological chemistry. 289(12):8326-36. 2014.
- Yuan Q, Han J, Cong W. Docetaxel-loaded solid lipid nanoparticles suppress breast cancer cells growth with reduced myelosuppression toxicity. International journal of nanomedicine. 9:4829-46. 2014.
- Koinuma J, Akiyama H, Fujita M. Characterization of an Opa interacting protein 5 involved in lung and esophageal carcinogenesis. Cancer science. 103(3):577-86. 2012.
- Gong M, Xu Y, Dong W. Expression of Opa interacting protein 5 (OIP5) is associated with tumor stage and prognosis of clear cell renal cell carcinoma. Acta histochemica. 115(8):810-5. 2013.