PD-L1/CD274 antibody

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  • 抗体类型:单克隆
  • 抗体来源:小鼠
  • 抗体应用:ELISA, WB, IHC, IF, FC
  • 特异性:Human, Mouse, Pig; other species not tested.

产品详情

  • 产品名称
    PD-L1/CD274 antibody
  • 抗体类型
    单克隆
  • 抗体来源
    小鼠
  • 抗体亚型
    小鼠IgG1
  • 抗体描述
    PD-L1/CD274 Mouse Monoclonal antibody. Positive IHC detected in human tonsillitis tissue, human heart tissue, human lung cancer tissue, human placenta tissue. Positive IF detected in HeLa cells. Positive FC detected in Raji cells. Positive WB detected in human skeletal muscle tissue, human placenta tissue, pig lung tissue, RAW 264.7 cells. Observed molecular weight by Western-blot: 50 kDa
  • 抗体应用
    ELISA, WB, IHC, IF, FC
  • 应用推荐

    Recommended Dilution:

    WB: 1:500-1:5000

    IHC: 1:100-1:500

    IF: 1:50-1:500

  • 特异性
    Human, Mouse, Pig; other species not tested.
  • 蛋白别名
    B7 H, B7 H1, B7 homolog 1, B7H1, CD274, CD274 molecule, PD L1, PDCD1 ligand 1, PDCD1L1, PDCD1LG1, PDL1, PD-L1, PD-L1/CD274, Programmed death ligand 1
  • 制备方法
    This antibody was obtained by immunization of PD-L1/CD274 recombinant protein (Accession Number: NM_014143). Purification method: Protein G purified.
  • 组分
    PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
  • 储存方法
    Store at -20℃. DO NOT ALIQUOT
  • 背景介绍
    Programmed cell death ligand 1(CD274, or B7-H1, PD-L1), is the first member of B7 family to be discovered. B7 family molecules are type I transmembrane proteins belonging to the immunoglobulin superfamily. In concert with their CD28 family receptors, the B7s are key regulators of the adaptive immune response. CD274 is suggested a negative regulator of T and B cell, and play important role in mediating tolerance of lymphocytes to self-antigens. It also involved in the costimulatory signal, essential for T-cell proliferation and production of IL10 and IFNG, in an IL2-dependent and a PDCD1-independent manner. Read more about this antibody on the blog: PD-L1 and Lung Cancer Research: Pathways to Promising Immunotherapies
声明：本公司出售产品只能用于科研目的，不得用于诊断或者治疗！