- 抗体应用:ELISA, WB, IHC, IF, FC
- 特异性:Human, Mouse, Pig; other species not tested.
PD-L1/CD274 Mouse Monoclonal antibody. Positive IHC detected in human tonsillitis tissue, human heart tissue, human lung cancer tissue, human placenta tissue. Positive IF detected in HeLa cells. Positive FC detected in Raji cells. Positive WB detected in human skeletal muscle tissue, human placenta tissue, pig lung tissue, RAW 264.7 cells. Observed molecular weight by Western-blot: 50 kDa
ELISA, WB, IHC, IF, FC
Human, Mouse, Pig; other species not tested.
B7 H, B7 H1, B7 homolog 1, B7H1, CD274, CD274 molecule, PD L1, PDCD1 ligand 1, PDCD1L1, PDCD1LG1, PDL1, PD-L1, PD-L1/CD274, Programmed death ligand 1
This antibody was obtained by immunization of PD-L1/CD274 recombinant protein (Accession Number: NM_014143). Purification method: Protein G purified.
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Store at -20℃. DO NOT ALIQUOT
Programmed cell death ligand 1(CD274, or B7-H1, PD-L1), is the first member of B7 family to be discovered. B7 family molecules are type I transmembrane proteins belonging to the immunoglobulin superfamily. In concert with their CD28 family receptors, the B7s are key regulators of the adaptive immune response. CD274 is suggested a negative regulator of T and B cell, and play important role in mediating tolerance of lymphocytes to self-antigens. It also involved in the costimulatory signal, essential for T-cell proliferation and production of IL10 and IFNG, in an IL2-dependent and a PDCD1-independent manner. Read more about this antibody on the blog: PD-L1 and Lung Cancer Research: Pathways to Promising Immunotherapies