- 抗体类型:多克隆
- 抗体来源:兔
- 抗体应用:ELISA, WB
- 特异性:Human,Mouse,Rat; other species not tested.
产品详情
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产品名称
PHF17 antibody
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抗体类型
多克隆
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抗体来源
兔
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抗体亚型
兔IgG
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抗体描述
PHF17 Rabbit Polyclonal antibody. Positive WB detected in HeLa cells, HEK-293 cells. Observed molecular weight by Western-blot: 58-61kd ,94-96kd
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抗体应用
ELISA, WB
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应用推荐
Recommended Dilution:
WB: 1:200-1:2000
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特异性
Human,Mouse,Rat; other species not tested.
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蛋白别名
FLJ22479, JADE1, KIAA1807, PHD finger protein 17, PHF17, Protein Jade 1
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制备方法
This antibody was obtained by immunization of PHF17 recombinant protein (Accession Number: NM_024900). Purification method: Antigen affinity purified.
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组分
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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储存方法
Store at -20℃. DO NOT ALIQUOT
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背景介绍
PHF17 was identified as a protein partner of the von Hippel-Lindau tumor suppressor pVHL. It is one component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. It can act as a transcriptional coactivator that promote acetylation of nucleosomal histone H4 by KAT5. In addition, it ubiquitinates both phosphorylated and non-phosphorylated β-catenin and therefore regulates canonical Wnt signaling in both Wnt-off and Wnt-on phases.
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参考文献
- Borgal L, Habbig S, Hatzold J. The ciliary protein nephrocystin-4 translocates the canonical Wnt regulator Jade-1 to the nucleus to negatively regulate β-catenin signaling. The Journal of biological chemistry. 287(30):25370-80. 2012.
- Borgal L, Rinschen MM, Dafinger C. Casein kinase 1 α phosphorylates the Wnt regulator Jade-1 and modulates its activity. The Journal of biological chemistry. 289(38):26344-56. 2014.