重组大鼠EDAR蛋白

大鼠

人胚胎肾细胞（HEK293）

Met 1 - Ala 187

A DNA sequence encoding the rat EDAR (NP_001178828.1) extracellular domain (Met 1-Ala 187) was fused with the Fc region of human IgG1 at the C-terminus.

> 95 % as determined by SDS-PAGE

The secreted recombinant rat EDAR/Fc is a disulfide-linked homodimer. The reduced monomer comprises 402 amino acids and predicts a molecular mass of 44.4 kDa. The apparent molecular mass of the ratEDAR/Fc monomer is approximately 60-70 kDa in SDS-PAGE under reducing conditions due to glycosylation.

ED3; DL; EDAR; HRM1; EDA-A1R; ECTD10B; EDA1R; ED1R; ECTD10A; ED5; FLJ94390; EDA3

Protein Edar

Tumor necrosis factor receptor superfamily member EDAR is a Single-pass type I membrane protein. Edar was expressed reiteratively in signaling centers regulating key steps in morphogenesis. activin signaling from mesenchyme induces the expression of the TNF receptor edar in the epithelial signaling centers, thus making them responsive to Wnt-induced ectodysplasin from the nearby ectoderm. This is the first demonstration of integration of the Wnt, activin, and TNF signaling pathways. Defects in EDAR are a cause of ectodermal dysplasia anhidrotic (EDA), also known ectodermal dysplasia hypohidrotic autosomal recessive (HED). Ectodermal dysplasia defines a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. EDA is characterized by sparse hair (atrichosis or hypotrichosis), abnormal or missing teeth and the inability to sweat due to the absence of sweat glands.

Lyophilized from sterile PBS, pH 7.4
1. 5 % trehalose and mannitol are added as protectants before lyophilization.
2. Please contact us for any concerns or special requirements.

< 1.0 EU per μg of the protein as determined by the LAL method

Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.