- 抗体类型:多克隆
- 抗体来源:兔
- 抗体应用:ELISA, IHC
- 特异性:Human, Mouse; other species not tested.
产品详情
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产品名称
PSEN2-Specific antibody
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抗体类型
多克隆
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抗体来源
兔
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抗体亚型
兔IgG
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抗体描述
PSEN2-Specific Rabbit Polyclonal antibody. Positive IHC detected in human kidney tissue, human breast cancer tissue, human colon tissue, human placenta tissue.
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抗体应用
ELISA, IHC
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应用推荐
Recommended Dilution:
IHC: 1:20-1:200
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特异性
Human, Mouse; other species not tested.
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蛋白别名
AD3L, AD3LP, AD4, AD5, E5 1, Presenilin 2, PS 2, PS2, PSEN2, PSNL2, STM 2, STM2
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制备方法
This antibody was obtained by immunization of Peptide (Accession Number: NM_000447). Purification method: Antigen affinity purified.
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组分
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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储存方法
Store at -20℃. DO NOT ALIQUOT
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背景介绍
Presenilins can regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. These transmembrane proteins are considered to be involved in early onset of Alzheimer's disease. Presenilin 2 mainly localizes in large neurons. It exists in a heterodimeric complex formed from the endoproteolytically processed amino-terminal (34 kDa) and carboxy-terminal (about 23 kDa) fragments.This antibody is specific to presenilin 2. It will not bind presenilin 1.