PTBP1 antibody

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  • 抗体类型:多克隆
  • 抗体来源:
  • 抗体应用:ELISA, WB, IF, IHC
  • 特异性:Human,Mouse,Rat; other species not tested.

产品详情

  • 产品名称
    PTBP1 antibody
  • 抗体类型
    多克隆
  • 抗体来源
  • 抗体亚型
    兔IgG
  • 抗体描述
    PTBP1 Rabbit Polyclonal antibody. Positive WB detected in Jurkat cells, BxPC-3 cells, HeLa cells, human lung tissue, K-562 cells, mouse lung tissue, rat heart tissue. Positive IHC detected in human prostate cancer tissue, human pancreas tissue. Positive IF detected in A2780 cells. Observed molecular weight by Western-blot: 59.6kd
  • 抗体应用
    ELISA, WB, IF, IHC
  • 应用推荐

    Recommended Dilution:

    WB: 1:1000-1:10000

    IHC: 1:20-1:200

    IF: 1:10-1:100

  • 特异性
    Human,Mouse,Rat; other species not tested.
  • 蛋白别名
    HNRNP I, HNRNPI, HNRPI, pPTB, PTB, PTB 1, PTB T, PTB2, PTB3, PTB4, PTBP1
  • 制备方法
    This antibody was obtained by immunization of PTBP1 recombinant protein (Accession Number: NM_002819). Purification method: Antigen affinity purified.
  • 组分
    PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
  • 储存方法
    Store at -20℃. DO NOT ALIQUOT
  • 背景介绍
    Polypyrimidine tract-binding protein (PTBP1), also known as heterogeneous nuclear ribonucleoprotein type I (hnRNP I), is a nuclear protein that binds pre-mRNAs in specific regions of the hnRNA-protein complexes sensitive to micrococcal nuclease. It involves in pre-mRNA splicing and the regulation of alternative splicing events. PTBP1 promotes RNA looping when bound to two separate polypyrimidine tracts in the same pre-mRNA, and promotes the binding of U2 snRNP to pre-mRNA. Besides, it can cooperate with RAVER1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA, and represses the splicing of MAPT/Tau exon 10
  • 参考文献
    • Guo R, Li Y, Ning J, Sun D, Lin L, Liu X. HnRNP A1/A2 and SF2/ASF regulate alternative splicing of interferon regulatory factor-3 and affect immunomodulatory functions in human non-small cell lung cancer cells. PloS one. 8(4):e62729. 2013.
    • Gallagher IJ, Scheele C, Keller P. Integration of microRNA changes in vivo identifies novel molecular features of muscle insulin resistance in type 2 diabetes. Genome medicine. 2(2):9. 2010.
    • Markus MA, Marques FZ, Morris BJ. Resveratrol, by modulating RNA processing factor levels, can influence the alternative splicing of pre-mRNAs. PloS one. 6(12):e28926. 2011.
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