- 抗体类型:多克隆
- 抗体来源:兔
- 抗体应用:ELISA, WB, IP
- 特异性:Human,Mouse,Rat; other species not tested.
产品详情
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产品名称
PXR antibody
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抗体类型
多克隆
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抗体来源
兔
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抗体亚型
兔IgG
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抗体描述
PXR Rabbit Polyclonal antibody. Positive WB detected in HepG2 cells, A549 cells, MCF7 cells, mouse colon tissue. Positive IP detected in HepG2 cells. Observed molecular weight by Western-blot: 45-50kd
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抗体应用
ELISA, WB, IP
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应用推荐
Recommended Dilution:
WB: 1:200-1:2000
IP: 1:200-1:2000
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特异性
Human,Mouse,Rat; other species not tested.
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蛋白别名
BXR, NR1I2, ONR1, Orphan nuclear receptor PAR1, Orphan nuclear receptor PXR, PAR, PAR1, PAR2, PARq, Pregnane X receptor, PRR, PXR, SAR, SXR
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制备方法
This antibody was obtained by immunization of PXR recombinant protein (Accession Number: NM_003889). Purification method: Antigen affinity purified.
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组分
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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储存方法
Store at -20℃. DO NOT ALIQUOT
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背景介绍
Pregnane X receptor (PXR; NR1I2), a member of the nuclear receptor superfamily, plays a key role in the induction of genes involved in drug transport and metabolism. It modulates drug transport and metabolism through the regulation of target genes responsible for the transport and conversion of chemicals into metabolites that are more easily eliminated from the body [PMID: 22609277]. It is also emerging as an endobiotic receptor that regulates the inflammatory response. In addition, PXR acts as a transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, drugs and endogenous compounds [PMID: 19297428].
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参考文献
- Zhou W, Lin J, Chen H, Wang J, Liu Y, Xia M. Retinoic acid induces macrophage cholesterol efflux and inhibits atherosclerotic plaque formation in apoE-deficient mice. The British journal of nutrition. 114(4):509-18. 2015.