重组小鼠Rspo2蛋白

小鼠

人胚胎肾细胞（HEK293）

Met 1 - Gly 205

A DNA sequence encoding the mouse Rspo2 (NP_766403.1) (Met1-Gly205) was expressed with the Fc region of mouse IgG1 at the C-terminus.

> 85 % as determined by SDS-PAGE.

The recombinant mouse Rspo2 consists 416 amino acids and predicts a molecular mass of 47.4 kDa.

ROOF PLATE-SPECIFIC SPONDIN-2; UNQ9384/PRO34209; R-SPONDIN 2 HOMOLOG; R-SPONDIN-2; FTLS; D430027K22; CRISTIN2; AA673245; 2610028F08RIK

R-spondin-2

Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Probably also acts as a ligand for frizzled and LRP receptors.

Lyophilized from sterile PBS, pH 7.4.
1. 5 % trehalose and mannitol are added as protectants before lyophilization.
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<1.0 EU per μg protein as determined by the LAL method.

Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.