重组小鼠Rspo2蛋白

产品详情

  • 产品名称
    重组小鼠Rspo2蛋白
  • 蛋白种属
    小鼠
  • 表达宿主
    人胚胎肾细胞(HEK293)
  • Unitprot ID
  • 蛋白序列
    Met 1 - Gly 205
  • 克隆构建
    A DNA sequence encoding the mouse Rspo2 (NP_766403.1) (Met1-Gly205) was expressed with the Fc region of mouse IgG1 at the C-terminus.
  • 蛋白纯度
    > 85 % as determined by SDS-PAGE.
  • 分子量
    The recombinant mouse Rspo2 consists 416 amino acids and predicts a molecular mass of 47.4 kDa.
  • 蛋白别名
    ROOF PLATE-SPECIFIC SPONDIN-2; UNQ9384/PRO34209; R-SPONDIN 2 HOMOLOG; R-SPONDIN-2; FTLS; D430027K22; CRISTIN2; AA673245; 2610028F08RIK
  • 蛋白全名
    R-spondin-2
  • 蛋白描述
    Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Probably also acts as a ligand for frizzled and LRP receptors.
  • 发货形式
    Lyophilized from sterile PBS, pH 7.4.
    1. 5 % trehalose and mannitol are added as protectants before lyophilization.
    2. Please contact us for any concerns or special requirements.
  • 内毒素
    <1.0 EU per μg protein as determined by the LAL method.
  • 保存条件
    Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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