- 抗体类型:多克隆
- 抗体来源:兔
- 抗体应用:ELISA, WB, IHC, IP
- 特异性:Human, Mouse; other species not tested.
产品详情
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产品名称
RAB22A antibody
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抗体类型
多克隆
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抗体来源
兔
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抗体亚型
兔IgG
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抗体描述
RAB22A Rabbit Polyclonal antibody. Positive IHC detected in human gliomas tissue. Positive IP detected in COLO 320 cells. Positive WB detected in BxPC-3 cells, COLO 320 cells, Jurkat cells. Observed molecular weight by Western-blot: 22 kDa
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抗体应用
ELISA, WB, IHC, IP
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应用推荐
Recommended Dilution:
WB: 1:200-1:2000
IP: 1:200-1:1000
IHC: 1:20-1:200
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特异性
Human, Mouse; other species not tested.
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蛋白别名
Rab 22, RAB22, RAB22A, Ras related protein Rab 22A
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制备方法
This antibody was obtained by immunization of RAB22A recombinant protein (Accession Number: NM_020673). Purification method: Antigen affinity purified.
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组分
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
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储存方法
Store at -20℃. DO NOT ALIQUOT
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背景介绍
RAB22A is a small GTPase that is expressed ubiquitously in mammalian tissues. It localizes in the MHCI-containing recycling endosomal tubules and functions in endocytic pathway. RAB22A may regulate the dynamic interactions of endosomal compartments and it may be involved in the communication between the biosynthetic and early endocytic pathways. It shares 81% identity with RAB31.
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参考文献
- Zhu H, Liang Z, Li G. Rabex-5 is a Rab22 effector and mediates a Rab22-Rab5 signaling cascade in endocytosis. Molecular biology of the cell. 20(22):4720-9. 2009.
- Wang L, Liang Z, Li G. Rab22 controls NGF signaling and neurite outgrowth in PC12 cells. Molecular biology of the cell. 22(20):3853-60. 2011.
- Seto S, Tsujimura K, Koide Y. Rab GTPases regulating phagosome maturation are differentially recruited to mycobacterial phagosomes. Traffic (Copenhagen, Denmark). 12(4):407-20. 2011.
- Wiesner C, El Azzouzi K, Linder S. A specific subset of RabGTPases controls cell surface exposure of MT1-MMP, extracellular matrix degradation and three-dimensional invasion of macrophages. Journal of cell science. 126(Pt 13):2820-33. 2013.
- Tanaka T, Arai M, Wu S. Epigenetic silencing of microRNA-373 plays an important role in regulating cell proliferation in colon cancer. Oncology reports. 26(5):1329-35. 2011.
- Margue C, Philippidou D, Reinsbach SE, Schmitt M, Behrmann I, Kreis S. New target genes of MITF-induced microRNA-211 contribute to melanoma cell invasion. PloS one. 8(9):e73473. 2013.
- Yuan F, Snapp EL, Novikoff PM. Human liver cell trafficking mutants: characterization and whole exome sequencing. PloS one. 9(1):e87043. 2014.
- Ahram DF, Cook AC, Kecova H, Grozdanic SD, Kuehn MH. Identification of genetic loci associated with primary angle-closure glaucoma in the basset hound. Molecular vision. 20:497-510. 2014.