- 抗体类型:多克隆
- 抗体来源:兔
- 抗体应用:ELISA, WB, IHC
- 特异性:human, mouse, rat; other species not tested.
产品详情
-
产品名称
RAD23B antibody
-
抗体类型
多克隆
-
抗体来源
兔
-
抗体亚型
兔IgG
-
抗体描述
RAD23B Rabbit Polyclonal antibody. Positive IHC detected in human breast cancer. Positive WB detected in Jurkat cells, HEK-293 cells, A431 cells, mouse kidney tissue. Observed molecular weight by Western-blot: 58kd
-
抗体应用
ELISA, WB, IHC
-
应用推荐
Recommended Dilution:
WB: 1:200-1:2000
IHC: 1:20-1:200
-
特异性
human, mouse, rat; other species not tested.
-
蛋白别名
RAD23B, HR23B, HHR23B, P58
-
制备方法
This antibody was obtained by immunization of RAD23B recombinant protein (Accession Number: NM_002874). Purification method: Antigen affinity purified.
-
组分
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
-
储存方法
Store at -20℃. DO NOT ALIQUOT
-
背景介绍
RAD23B, also named as p58, hHR23B and HR23B, belongs to the RAD23 family. It plays a central role both in proteosomal degradation of misfolded proteins and DNA repair. RAD23B is a central component of a complex required to couple deglycosylation and proteasome-mediated degradation of misfolded proteins in the endoplasmic reticulun that are retrotranslocated in the cytosol. Involved in DNA excision repair by stabilizing XPC protein. It may play a part in DNA damage recognition and/or in altering chromatin structure to allow access by damage-processing enzymes. RAD23B has two subunit: Heterodimer of a 125 kDa subunit (p125) and of a 58 kDa subunit (p58).
-
参考文献
- Wear MP, Kryndushkin D, O'Meally R, Sonnenberg JL, Cole RN, Shewmaker FP. Proteins with Intrinsically Disordered Domains Are Preferentially Recruited to Polyglutamine Aggregates. PloS one. 10(8):e0136362. 2015.