重组人RAB31蛋白

人

大肠杆菌

Met 1 - Cys 195

A DNA sequence encoding the human RAB31 (NP_006859.2) (Met1-Cys195) was expressed with a polyhistidine tag at the N-terminus.

> 90 % as determined by SDS-PAGE

The recombinant human RAB31 consists of 213 amino acids and predicts a molecular mass of 23.9 kDa. It migrates as an approximately 26 kDa band in SDS-PAGE under reducing conditions.

AI415285; 1700093E07RIK ; RAB22B; 1700093E07RIK

Ras-related protein Rab-31

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Required for the integrity and for normal function of the Golgi apparatus and the trans-Golgi network. Plays a role in insulin-stimulated translocation of GLUT4 to the cell membrane. Plays a role in M6PR transport from the trans-Golgi network to endosomes. Plays a role in the internalization of EGFR from the cell membrane into endosomes. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis.

Lyophilized from sterile 50 mM Tris, pH 8.0.
1. 5 % trehalose and mannitol are added as protectants before lyophilization.
2. Please contact us for any concerns or special requirements.

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Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.