RBM4 antibody

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  • 抗体类型:多克隆
  • 抗体来源:兔
  • 抗体应用:ELISA, WB, IHC, IF, IP
  • 特异性:Human,Mouse,Rat; other species not tested.

产品详情

  • 产品名称
    RBM4 antibody
  • 抗体类型
    多克隆
  • 抗体来源
    兔
  • 抗体亚型
    兔IgG
  • 抗体描述
    RBM4 Rabbit Polyclonal antibody. Positive IP detected in mouse heart tissue. Positive WB detected in mouse brain tissue, human brain tissue, human heart tissue, human kidney tissue. Positive IF detected in HepG2 cells. Positive IHC detected in human gliomas tissue, human lung cancer tissue. Observed molecular weight by Western-blot: 37-40 kDa
  • 抗体应用
    ELISA, WB, IHC, IF, IP
  • 应用推荐

    Recommended Dilution:

    WB: 1:500-1:5000

    IP: 1:500-1:5000

    IHC: 1:20-1:200

    IF: 1:20-1:200

  • 特异性
    Human,Mouse,Rat; other species not tested.
  • 蛋白别名
    DKFZp547K0918, hLark, LARK, Lark homolog, RBM4, RBM4A, RNA binding motif protein 4, RNA binding motif protein 4a, RNA binding protein 4, ZCCHC21, ZCRB3A
  • 制备方法
    This antibody was obtained by immunization of RBM4 recombinant protein (Accession Number: BC021120). Purification method: Antigen affinity purified.
  • 组分
    PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
  • 储存方法
    Store at -20℃. DO NOT ALIQUOT
  • 背景介绍
    RBM4, RNA-binding motif protein4, contains 2 RRM-type RNA-binding motif and a retroviral-type(RT) zinc finger. RNA-binding factor participates in number of aspects of cellular processes such as alternative splicing of pre-mRNA and translation regulation. RBM4 recruits eIF4A1 to stimulate IRES-dependent translation in responds to cellular stress. Once assembled at the rHRE, the HIF2A-RBM4-eIF4E2 complex captures the 5-prime cap and targets mRNAs to polysomes for active translation, thereby evading hypoxia-induced repression of protein synthesis. This is a rabbit polyclonal antibody raised against the full-length of human RBM4
  • 参考文献
    • Wang Y, Chen D, Qian H. The splicing factor RBM4 controls apoptosis, proliferation, and migration to suppress tumor progression. Cancer cell. 26(3):374-89. 2014.
    • Markus MA, Marques FZ, Morris BJ. Resveratrol, by modulating RNA processing factor levels, can influence the alternative splicing of pre-mRNAs. PloS one. 6(12):e28926. 2011.
    • Uniacke J, Holterman CE, Lachance G. An oxygen-regulated switch in the protein synthesis machinery. Nature. 486(7401):126-9. 2012.
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