重组恒河猴EGFR蛋白

恒河猴

杆状病毒 - 昆虫细胞

Met 1 - Ser 645

A DNA sequence encoding the rhesus EGFR (XP_001107305.1) (Met1-Ser645) was expressed with a polyhistidine tag at the C-terminus.

> 95 % as determined by SDS-PAGE.

The recombinant rhesus EGFR consists 632 amino acids and predicts a molecular mass of 70.1 kDa.

ERRP; ERBB1; NISBD2; WA2; ERRB1; ERBB; RP23-295E4.1; AI552599; WA-2; EGFR; PIG61; MENA; HER1; ERBB-1; 9030024J15RIK; WA5

As a member of the epidermal growth factor receptor (EGFR) family, EGFR protein is type I transmembrane glycoprotein that binds a subset of EGF family ligands including EGF, amphiregulin, TGF-α, betacellulin, etc. EGFR protein plays a crucial role in signaling pathway in the regulation of cell proliferation, survival and differentiation. Binding of a ligand induces EGFR protein homo- or heterodimerization, the subsequent tyrosine autophosphorylation and initiates various down stream pathways (MAPK, PI3K/PKB and STAT). In addition, EGFR signaling also has been shown to exert action on carcinogenesis and disease progression, and thus EGFR protein is proposed as a target for cancer therapy currently.

Lyophilized from sterile 20 mM Tris, 500 mM NaCl, 10 % glycerol, pH 8.0.
1. 5 % trehalose and mannitol are added as protectants before lyophilization.
2. Please contact us for any concerns or special requirements.

<1.0 EU per μg protein as determined by the LAL method.

Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.