Spartin, SPG20 antibody

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  • 抗体类型:多克隆
  • 抗体来源:兔
  • 抗体应用:ELISA, IHC, IF, IP, WB, FC
  • 特异性:Human,Mouse,Rat; other species not tested.

产品详情

  • 产品名称
    Spartin, SPG20 antibody
  • 抗体类型
    多克隆
  • 抗体来源
    兔
  • 抗体亚型
    兔IgG
  • 抗体描述
    Spartin, SPG20 Rabbit Polyclonal antibody. Positive IP detected in mouse brain tissue. Positive WB detected in NIH/3T3 cells, HEK-293 cells, HeLa cells, human brain tissue, mouse brain tissue, rat brain tissue, SH-SY5Y cells. Positive FC detected in HepG2 cells. Positive IHC detected in human gliomas tissue. Positive IF detected in HepG2 cells. Observed molecular weight by Western-blot: 75 kDa,84 kDa
  • 抗体应用
    ELISA, IHC, IF, IP, WB, FC
  • 应用推荐

    Recommended Dilution:

    WB: 1:500-1:5000

    IP: 1:500-1:5000

    IHC: 1:20-1:200

    IF: 1:10-1:100

  • 特异性
    Human,Mouse,Rat; other species not tested.
  • 蛋白别名
    KIAA0610, SPARTIN, Spastic paraplegia 20 protein, SPG20, TAHCCP1
  • 制备方法
    This antibody was obtained by immunization of Spartin, SPG20 recombinant protein (Accession Number: NM_015087). Purification method: Antigen affinity purified.
  • 组分
    PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
  • 储存方法
    Store at -20℃. DO NOT ALIQUOT
  • 背景介绍
    SPG20 (spastic paraplegia 20) gene encodes a multifunctional Spartin protein. SPG20 protein is highly expressed in adipose tissue and may be implicated in endosomal trafficking and microtubule dynamics. SPG20 is mutated in Troyer syndrome, a hereditary spastic paraplegia defined by degeneration of upper motor neurons, recent study showed that regulation of SPG20 on mitochondrial calcium homeostasis may contribute to the pathophysiology of Troyer syndrome. Hypermethylation of SPG20 promoter, found in colorectal cancer paitents, may play a role in cytokinesis arrest in colorectal tumorigenesis.
  • 参考文献
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