- 抗体类型:多克隆
- 抗体来源:兔
- 抗体应用:ELISA, IHC, IP, WB
- 特异性:Human, Mouse, Rat; other species not tested.
产品详情
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产品名称
STMN3 antibody
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抗体类型
多克隆
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抗体来源
兔
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抗体亚型
兔IgG
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抗体描述
STMN3 Rabbit Polyclonal antibody. Positive IP detected in mouse brain tissue. Positive WB detected in human brain tissue, rat brain tissue. Positive IHC detected in human colon cancer tissue. Observed molecular weight by Western-blot: 21-25kd
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抗体应用
ELISA, IHC, IP, WB
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应用推荐
Recommended Dilution:
WB: 1:1000-1:10000
IP: 1:1000-1:10000
IHC: 1:20-1:200
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特异性
Human, Mouse, Rat; other species not tested.
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蛋白别名
SCG10 like protein, SCLIP, Stathmin 3, stathmin like 3, STMN3
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制备方法
This antibody was obtained by immunization of STMN3 recombinant protein (Accession Number: NM_015894). Purification method: Antigen affinity purified.
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组分
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
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储存方法
Store at -20℃. DO NOT ALIQUOT
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背景介绍
Stathmin family phosphoproteins participate in the control of microtubule dynamics and have been proposed to be involved in the control of neuronal differentiation. Neuron specific Stathmin-3 (STMN3) is a novel STAT3 (signal transducer and activator of transcription 3) interacting protein. STAT3 is a key contributor to cancer cell migration and invasion. STMN3 exhibits microtubule-destabilizing activity, which is antagonized by STAT3. SCG10 is a widely studied and recognized neuronal differentiation marker, STMN3 is a SCG10-like protein (SCLIP) and is present from the earliest stages of hippocampal neuron differentiation in culture at vesicle-like structures following dynamic microtubules. RNAi mediated inhibition of this gene resulted in increased axonal branching.
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参考文献
- Xie X, Bartholomeusz C, Ahmed AA. Bisphosphorylated PEA-15 sensitizes ovarian cancer cells to paclitaxel by impairing the microtubule-destabilizing effect of SCLIP. Molecular cancer therapeutics. 12(6):1099-111. 2013.
- Singer S, Malz M, Herpel E. Coordinated expression of stathmin family members by far upstream sequence element-binding protein-1 increases motility in non-small cell lung cancer. Cancer research. 69(6):2234-43. 2009.