- 抗体类型:多克隆
- 抗体来源:兔
- 抗体应用:ELISA, WB, IHC, IF, IP
- 特异性:Human,Mouse,Rat; other species not tested.
产品详情
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产品名称
TRBP antibody
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抗体类型
多克隆
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抗体来源
兔
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抗体亚型
兔IgG
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抗体描述
TRBP Rabbit Polyclonal antibody. Positive IP detected in mouse liver tissue. Positive WB detected in HepG2 cells, mouse liver tissue, mouse spleen tissue. Positive IF detected in Hela cells. Positive IHC detected in human brain tissue, human kidney tissue, human ovary tissue, human placenta tissue, human spleen tissue, human testis tissue. Observed molecular weight by Western-blot: 43-46 kDa
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抗体应用
ELISA, WB, IHC, IF, IP
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应用推荐
Recommended Dilution:
WB: 1:500-1:5000
IP: 1:500-1:5000
IHC: 1:20-1:200
IF: 1:10-1:100
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特异性
Human,Mouse,Rat; other species not tested.
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蛋白别名
LOQS, TAR RNA binding protein 2, TARBP2, TRBP, TRBP1, TRBP2
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制备方法
This antibody was obtained by immunization of TRBP recombinant protein (Accession Number: NM_134323). Purification method: Antigen affinity purified.
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组分
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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储存方法
Store at -20℃. DO NOT ALIQUOT
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背景介绍
TARBP2 is a component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC). Within the complex, TARBP2 and DICER1 are required to process precursor miRNAs (pre-miRNA) to mature miRNA and then load them onto EIF2C2/AGO2. It may has a role in the production of short interfering RNAs (siRNAs) from double-stranded RNA (dsRNA) by DICER1. Otherwise, it binds to the HIV-1 TAR RNA that is located in the long terminal repeat (LTR) of HIV-1, and stimulates translation of TAR-containing RNAs.
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参考文献
- Chen C, Zhu C, Huang J. SUMOylation of TARBP2 regulates miRNA/siRNA efficiency. Nature communications. 6:8899. 2015.