重组小鼠Tnfrsf11b蛋白

小鼠

人胚胎肾细胞（HEK293）

Met 1 - Leu 401

A DNA sequence encoding the mouse Tnfrsf11b (NP_032790.3) (Met1-Leu401) was expressed with the Fc region of human IgG1 at the C-terminus.

> 95 % as determined by SDS-PAGE.

The recombinant mouse Tnfrsf11b consists 618 amino acids and predicts a molecular mass of 70.2 kDa.

TNFRSF11B; TR1; OSTEOPROTEGERIN; MGC29565; OPG; OCIF

Tumor necrosis factor receptor superfamily member 11B

Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. May also play a role in preventing arterial calcification. May act as decoy receptor for TNFSF10/TRAIL and protect against apoptosis. TNFSF10/TRAIL binding blocks the inhibition of osteoclastogenesis.

Lyophilized from sterile PBS, pH 7.4.
1. 5 % trehalose and mannitol are added as protectants before lyophilization.
2. Please contact us for any concerns or special requirements.

< 1.0 EU per μg protein as determined by the LAL method.

Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.