重组狗IGFBP1蛋白

狗

人胚胎肾细胞（HEK293）

Met 1 - Ser 249

A DNA sequence encoding the canine IGFBP1 (XP_005629556.1) (Met1-Ser249) was expressed with a polyhistidine tag at the C-terminus.

> 95 % as determined by SDS-PAGE.

The recombinant canine IGFBP1 consists 235 amino acids and predicts a molecular mass of 26 kDa.

INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 1 PRECURSOR (IGFBP-1) (IBP-1) (IGF-BINDING PROTEIN 1); PP12; AFBP; INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN 1; IGF-BP25; IBP1; HIGFBP-1; IGF-BINDING PROTEIN 1; IGFBP-1; RP23-20C9.2; IBP-1

Uncharacterized protein

IGFBP1, also known as IGFBP-1 and insulin-like growth factor-binding protein 1, is a member of the insulin-like growth factor binding protein family. IGF binding proteins (IGFBPs) are proteins of 24 to 45 kDa. All six IGFBPs share 50% homology with each other and have binding affinities for IGF-I and IGF-II at the same order of magnitude as the ligands have for the IGF-IR. IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. IGFBP1 has an IGFBP domain and a thyroglobulin type-I domain. It binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors.

Lyophilized from sterile PBS, pH 7.4.
1. 5 % trehalose and mannitol are added as protectants before lyophilization.
2. Please contact us for any concerns or special requirements.

< 1.0 EU per μg protein as determined by the LAL method.

Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.