- 抗体类型:多克隆
- 抗体来源:兔
- 抗体应用:ELISA, WB, IHC, IF
- 特异性:Human; other species not tested.
产品详情
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产品名称
Zinc-alpha-2-glycoprotein antibody
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抗体类型
多克隆
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抗体来源
兔
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抗体亚型
兔IgG
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抗体描述
Zinc-alpha-2-glycoprotein Rabbit Polyclonal antibody. Positive WB detected in PC-3 cells, MCF7 cells. Positive IHC detected in human breast cancer tissue. Positive IF detected in PC-3 cells. Observed molecular weight by Western-blot: 41 kDa or 33 kDa
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抗体应用
ELISA, WB, IHC, IF
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应用推荐
Recommended Dilution:
WB: 1:500-1:5000
IHC: 1:20-1:200
IF: 1:20-1:200
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特异性
Human; other species not tested.
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蛋白别名
AZGP1, ZA2G, ZAG, Zinc-alpha-2-glycoprotein, Zn alpha 2 glycoprotein, Zn alpha 2 GP, ZNGP1
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制备方法
This antibody was obtained by immunization of Zinc-alpha-2-glycoprotein recombinant protein (Accession Number: NM_001185). Purification method: Antigen affinity purified.
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组分
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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储存方法
Store at -20℃. DO NOT ALIQUOT
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背景介绍
Zinc-alpha-2-glycoprotein (AZGP1) is a soluble protein normally found in body fluids, functions as a lipid mobilizing factor (PMID: 19188554). It is known to be expressed in the secretory epithelia of the liver, lung, breast, GI tract and sweat glands, sharing significant structural similarity with the class I major histocompatibility complex (MHC) antigens (PMID: 3422450). AZGP1 is involved in carcinogenesis and differentiation. Altered expression of AZGP1 has been reported in breast cancer, prostate cancer and lung adenocarcinoma, hepatocellular carcinoma, pancreatic carcinoma and oral tumors (PMID: 22625427).
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参考文献
- Lu CM, Wu YJ, Chen CC. Identification of low-abundance proteins via fractionation of the urine proteome with weak anion exchange chromatography. Proteome science. 9:17. 2011.
- Huang Y, Li LZ, Zhang CZ. Decreased expression of zinc-alpha2-glycoprotein in hepatocellular carcinoma associates with poor prognosis. Journal of translational medicine. 10:106. 2012.
- Balaz M, Vician M, Janakova Z. Subcutaneous adipose tissue zinc-α2-glycoprotein is associated with adipose tissue and whole-body insulin sensitivity. Obesity (Silver Spring, Md.). 22(8):1821-9. 2014.
- Burdelski C, Kleinhans S, Kluth M. Reduced AZGP1 expression is an independent predictor of early PSA recurrence and associated with ERG-fusion positive and PTEN deleted prostate cancers. International journal of cancer. 138(5):1199-206. 2016.