- 抗体类型:单克隆
- 抗体来源:小鼠
- 抗体应用:ELISA, WB, IF, IHC
- 特异性:Human, Mouse, Rat; other species not tested.
产品详情
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产品名称
ALDH1A1 antibody
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抗体类型
单克隆
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抗体来源
小鼠
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抗体亚型
小鼠IgG1
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抗体描述
ALDH1A1 Mouse Monoclonal antibody. Positive IF detected in A431 cells, HeLa cells. Positive IHC detected in human brain tissue. Positive WB detected in MCF7 cell, rat liver tissue. Observed molecular weight by Western-blot: 52 kDa
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抗体应用
ELISA, WB, IF, IHC
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应用推荐
Recommended Dilution:
WB: 1:200-1:2000
IHC: 1:50-1:500
IF: 1:10-1:100
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特异性
Human, Mouse, Rat; other species not tested.
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蛋白别名
ALDC, ALDH E1, ALDH1, ALDH11, ALDH1A1, ALHDII, PUMB1, RALDH 1, RALDH1, Retinal dehydrogenase 1
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制备方法
This antibody was obtained by immunization of ALDH1A1 recombinant protein (Accession Number: NM_000689). Purification method: Protein G purified.
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组分
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
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储存方法
Store at -20℃. DO NOT ALIQUOT
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背景介绍
ALDH1A1(Aldehyde dehydrogenase family 1 member A1 ), also named as ALDC, ALDH1 and PUMB1, belongs to the aldehyde dehydrogenase family. The ALDH1A1 gene encodes a liver cytosolic isoform of acetaldehyde dehydrogenase, an enzyme involved in the major pathway of alcohol metabolism after alcohol dehydrogenase. ALDH1A1 plays a critical role in protection against oxidative stress-induced cytotoxicity in lens epithelial cells(PMID:19296407). And it is important for multiple biological activities including drug resistance, cell differentiation, and oxidative stress response(PMID:19025616). As a novel cancer stem cell marker, ALDH1A1 can be used for tumors whose corresponding normal tissues express ALDH1A1 in relatively restricted or limited levels such as breast, lung, ovarian or colon cancer(PMID: 20422001).