- 抗体类型:单克隆
- 抗体来源:兔
- 抗体应用:WB, IHC-P
- 特异性:Human, Mouse, Rat
产品详情
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产品名称
Anti-hnRNP K Rabbit antibody
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抗体类型
单克隆
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抗体来源
兔
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抗体亚型
兔IgG
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抗体描述
hnRNP K Rabbit monoclonal antibody
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抗体应用
WB, IHC-P
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应用推荐
WB: 1/1000-1/5000
IHC: 1/20-1/50
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特异性
Human, Mouse, Rat
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蛋白别名
AUKS; CSBP; TUNP; HNRPK
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制备方法
Antigen: A synthetic peptide of human hnRNP K
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组分
50nM Tris-Glycine(pH 7.4), 0.15M Nacl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
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储存方法
Store at 4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
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背景介绍
Swiss-Prot Acc.P61978.One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction . As far as transcription repression is concerned, acts by interacting with long intergenic RNA p21 (lincRNA-p21), a non-coding RNA induced by p53/TP53. This interaction is necessary for the induction of apoptosis, but not cell cycle arrest.