- 抗体类型:单克隆
- 抗体来源:兔
- 抗体应用:WB, ICC/IF, IP
- 特异性:Human, Mouse, Rat
产品详情
-
产品名称
Anti-Phospho-MCM2 (Ser108) Rabbit antibody
-
抗体类型
单克隆
-
抗体来源
兔
-
抗体亚型
兔IgG
-
抗体描述
Phospho-MCM2 (Ser108) Rabbit monoclonal antibody
-
抗体应用
WB, ICC/IF, IP
-
应用推荐
1:1000
1:50
1:20
-
特异性
Human, Mouse, Rat
-
蛋白别名
BM28; CCNL1; CDCL1; cdc19; DFNA70; D3S3194; MITOTIN
-
制备方法
Antigen: A synthetic phosphopeptide corresponding to residues surrounding Ser108 of human MCM2
-
组分
Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M Nacl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
-
储存方法
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze / thaw cycle.
-
背景介绍
Swiss-Prot Acc.P49736.Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for the entry in S phase and for cell division. Plays a role in terminally differentiated hair cells development of the cochlea and induces cells apoptosis.