- 抗体类型:单克隆
- 抗体来源:小鼠
- 抗体应用:WB, IP
- 特异性:Human
产品详情
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产品名称
Anti-STAT5B (7H9) Mouse antibody
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抗体类型
单克隆
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抗体来源
小鼠
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抗体亚型
小鼠IgG1
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抗体描述
STAT5B (7H9) Mouse monoclonal antibody
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抗体应用
WB, IP
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应用推荐
WB: 1/500 - 1/2000
ELISA: 1/10000
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特异性
Human
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制备方法
Antigen: Purified recombinant fragment of human STAT5B expressed in E. Coli.
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组分
Ascitic fluid containing 0.03% sodium azide.
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储存方法
Store at 4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
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背景介绍
Swiss-Prot Acc.P51692.The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL.