重组人CEACAM1蛋白

人

人胚胎肾细胞（HEK293）

A DNA sequence encoding the extracellular domain of human CEACAM1 (NP_001020083.1) (Met 1-Gly 428) was expressed with a C-terminal polyhistidine tag.

> 95 % as determined by SDS-PAGE

1. Measured by its ability to bind biotinylated Human CEACAM6-His (Cat:504540) in functional ELISA.
2. Measured by its ability to bind biotinylated Human CEACAM8-His (Cat:500519) in functional ELISA.

The secreted recombinant human CEACAM1 comprises 405amino acids and predicts a molecular mass of 45 kDa. As a result of glycosylation, the apparent molecular mass of rhCEACAM1 is approximately 65-85 kDa in SDS-PAGE under reducing conditions.

HV2; HV-2; MMCGM1A; C-CAM; CEA-1; BGPI; CC1; MHVR; CEA7; BGP1; MMCGM2; MHVR1; BGP; MHV-1; CEA1; CEA-7; MMCGM1; BB-1; CD66A; CEACAM1; MCEA1

Carcinoembryonic antigen-related cell adhesion molecule 1

The carcinoembryonic-antigen-related cell-adhesion molecule (CEACAM) family of proteins has been implicated in various intercellular-adhesion and intracellular-signalling-mediated effects that govern the growth and differentiation of normal and cancerous cells. CEACAM1, also known as biliary glycoprotein I (BGP I) and CD66a, is a member of the carcinoembryonic antigen (CEA) gene family which belongs to the immunoglobulin superfamily. The highly glycosylated CEACAM1 contains one N-terminal V-type Ig-like domain and three C2-type Ig-like domains within its ECD, and one ITIM motif and a calmodulin binding site in the cytoplasmic region. CEACAM1 is a surface glycoprotein expressed on various blood cells, epithelial cells, and vascular cells. It was described as an adhesion molecule mediating cell adhesion via both homophilic and heterophilic manners, and was detected on leukocytes, epithelia, and endothelia. Studies have revealed that CEACAM1 performs actions in multiple cellular processes including tissue differentiation, angiogenesis, apoptosis, metastasis, as well as the modulation of innate and adaptive immune responses.

Lyophilized from sterile PBS, pH 7.4
1. 5 % trehalose and mannitol are added as protectants before lyophilization.
2. Please contact us for any concerns or special requirements.

< 1.0 EU per μg of the protein as determined by the LAL method

Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.