- 抗体类型:多克隆
- 抗体来源:兔
- 抗体应用:ELISA, WB, IP, IF
- 特异性:Human, Mouse, Rat; other species not tested.
产品详情
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产品名称
EZH2 antibody
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抗体类型
多克隆
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抗体来源
兔
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抗体亚型
兔IgG
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抗体描述
EZH2 Rabbit Polyclonal antibody. Positive IP detected in HepG2 cells. Positive WB detected in Raji cells, A431 cells, BxPC-3 cells, DU 145 cells, HEK-293 cells, HepG2 cells, Jurkat cells, mouse kidney tissue, NIH/3T3 cells, rat kidney tissue. Positive IF detected in HepG2 cells. Observed molecular weight by Western-blot: 90-102 kDa
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抗体应用
ELISA, WB, IP, IF
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应用推荐
Recommended Dilution:
WB: 1:1000-1:10000
IP: 1:500-1:5000
IF: 1:20-1:200
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特异性
Human, Mouse, Rat; other species not tested.
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蛋白别名
Enhancer of zeste homolog 2, ENX 1, EZH1, EZH2, KMT6, Lysine N methyltransferase 6
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制备方法
This antibody was obtained by immunization of EZH2 recombinant protein (Accession Number: NM_004456). Purification method: Antigen affinity purified.
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组分
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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储存方法
Store at -20℃. DO NOT ALIQUOT
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背景介绍
EZH2 (enhancer of zeste homologue 2, also known as KMT6) is a member of Polycomb group (PcG) family and encodes a histone methyl transferase that has an essential role in promoting histone H3 lysine 27 trimethylation (H3K27me3) and epigenetic gene silencing. EZH2 is important for cell proliferation and inhibition of cell differentiation, and is implicated in cancer progression. Overexpression of EZH2 is a marker of advanced and metastatic disease in many solid tumors, including prostate and breast cancer. This antibody detected EZH2 protein as a single band with a molecular weight (MW) of 91-100 kDa in multiple cell lines. The phosphorylation may result in the higher molecular weight (calculated MW as 80-86 kDa). (20935635, 21367748)
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参考文献
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