重组人CXCL1蛋白
- 蛋白种属:人
- 表达宿主:大肠杆菌
- Unitprot ID:P09341
产品详情
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产品名称
重组人CXCL1蛋白
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蛋白种属
人
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表达宿主
大肠杆菌
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Unitprot ID
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克隆构建
A DNA sequence encoding the mature form of human CXCL1 (P09341-1) (Ala 35-Asn 107) was fused with a N-terminal polyhistide-tagged SUMO tag at the N-terminus.
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蛋白纯度
> 97 % as determined by SDS-PAGE
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分子量
The recombinant human CXCL1 consisting of 189 amino acids and has a calculated molecular mass of 21.3 kDa. It migrates as an 30 kDa band in SDS-PAGE under reducing conditions.
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蛋白别名
GRO1; GRO; CXCL1; KC; SCYB1; GROA; MGSA-A; N51; MGSA; FSP; NAP-3
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蛋白全名
Growth-regulated alpha protein
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蛋白描述
The Chemokine (C-X-C motif) Ligand 1, CXCL1, is a small cytokine belonging to the CXC chemokine family that was previously called GRO1 oncogene, GRO?, KC, Neutrophil-activating protein 3 (NAP-3) and melanoma growth stimulating activity, alpha (MSGA-a). CXCL1 already known to be important in osteoarthritis (OA), as a novel target gene of transcription factor AP-2? in chondrocytes and support the important role of AP-2? in cartilage. CXCL1 is a potent neutrophil chemoattractant with recognized roles in angiogenesis and inflammation. CXCL1 is a novel immediate PTH/PTHrP-responsive gene. CXCL1 may act as a chemoattractant for osteoclast precursors. CXCL1 may also have important pro-nociceptive effects via its direct actions on sensory neurons, and may induce long-term changes that involve protein synthesis. CXCL1 plays a critical nonredundant role in the development of experimental Lyme arthritis and carditis via CXCR2-mediated recruitment of neutrophils into the site of infection. CXCL1 functions through CXCR2 to transactivate the EGFR by proteolytic cleavage of HB-EGF, leading to activation of MAPK signalling and increased proliferation of epithelial ovarian cancer (EOC) cells. It might limit tumor growth by reinforcing senescence early in tumorigenesis. Thus, CXCL1 plays a role in spinal cord development by inhibiting the migration of oligodendrocyte precursors and is involved in the processes of angiogenesis, inflammation, wound healing, and tumorigenesis.
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发货形式
Lyophilized from sterile PBS, pH 7.4, 10% glycerol
1. 5 % trehalose and mannitol are added as protectants before lyophilization.
2. Please contact us for any concerns or special requirements.
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内毒素
Please contact us for more information.
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保存条件
Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
重组蛋白定制服务:
纽普生物(NovoPro)提供大肠杆菌、哺乳细胞、昆虫细胞和酵母细胞重组蛋白定制服务
声明:本公司出售产品只能用于科研目的,不得用于诊断或者治疗!