重组人HPGD蛋白

人

人胚胎肾细胞（HEK293）

A DNA sequence encoding the Human HPGD/PGDH1/SDR36C1 Met1-Gln266 is expressed with a 6His tag at the C-terminus.

>95% as determined by SDS-PAGE.

PGDH1; SDR36C1

hydroxyprostaglandin dehydrogenase 15-(NAD)(HPGD)

15-hydroxyprostaglandin dehydrogenase [NAD(+)], also known as Prostaglandin dehydrogenase 1, 15-PGDH, HPGD and PGDH1, belongs to the short-chain dehydrogenases/reductases (SDR) family. HPGD localizes to the cytoplasm and can be found in colon epithelium, existing as a homodimer. HPGD catalyzes the NAD-dependent dehydrogenation of lipoxin A4 to form 15-oxo-lipoxin A4. HPGD is down-regulated by cortisol, dexamethasone and betamethasone, up-regulated by TGFB1. HPGD inhibits in vivo proliferation of colon cancer cells. HPGD is the key enzyme for the inactivation of prostaglandins, and thus regulates processes such as inflammation or proliferation.

Supplied as a 0.2 μm filtered solution of 20mM HEPES,150mM NaCl,pH7.4.

<1.0 EU per μg protein as determined by the LAL method.

Store at <-20°C, minimize freeze-thaw cycles.