重组人NRG1蛋白

产品详情

  • 产品名称
    重组人NRG1蛋白
  • 蛋白种属
    人
  • 表达宿主
    人胚胎肾细胞（HEK293）
  • Unitprot ID
    Q02297
  • 克隆构建
    A DNA sequence encoding the human NRG1 isoform alpha (Q02297-1) extracellular domain (Ser 20-Lys 241) was fused with the Fc region of human IgG1 at the C-terminus.
  • 蛋白纯度
    > 87 % as determined by SDS-PAGE
  • 蛋白活性
    1. Measured by its ability to biotinylated Human ErbB4-Fc (cat:503621) in functional Elisa.
    2. Measured by its ability to biotinylated Rhesus ErbB3-His (Cat:504642) in functional Elisa.
    3. Measured by its ability to biotinylated Rhesus ErbB3 (Cat:504643) in functional Elisa.
  • 分子量
    The recombinant human NRG1/Fc chimera is a disulfide-linked homodimeric protein. The reduced monomer consists of 463 amino acids and has a calculated molecular mass of 51 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rh NRG1/Fc monomer is approximately 60 kDa.
  • 蛋白别名
    HRG1; MSTP131; GGF; MST131; SMDF; GGFII; NRG1-IT2; HRG; NDF; HGL; ARIA; HRGA; HRGALPHA; D230005F13RIK; 6030402G23RIK; GGF2
  • 蛋白全名
    Pro-neuregulin-1, membrane-bound isoform
  • 蛋白描述
    Neuregulin 1 or NRG1 is one of four proteins in the neuregulin family that act on the EGFR family of receptors. This growth factor was originally identified as a 44-kD glycoprotein that interacts with the NEU / ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues. NRG1 is a trophic factor that has been implicated in neural development, neurotransmission, and synaptic plasticity. NRG1 has multiple isoforms that are generated by usage of different promoters and alternative splicing of a single gene. Neuregulin 1 (NRG1) is essential for the development and function of multiple organ systems, and its dysregulation has been linked to diseases such as cancer and schizophrenia. NRG1 is a schizophrenia candidate gene and plays an important role in brain development and neural function. Schizophrenia is a complex disorder, with etiology likely due to epistasis. 
  • 发货形式
    Lyophilized from sterile PBS, pH 7.4
    1. 5 % trehalose and mannitol are added as protectants before lyophilization.
    2. Please contact us for any concerns or special requirements.
  • 内毒素
    < 1.0 EU per μg of the protein as determined by the LAL method
  • 保存条件
    Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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