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- 抗体类型:多克隆
- 抗体来源:兔
- 抗体应用:ELISA, WB, IP, IF, IHC
- 特异性:Human,Mouse,Rat; other species not tested.
产品详情
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产品名称
IGF1A-Specific antibody
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抗体类型
多克隆
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抗体来源
兔
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抗体亚型
兔IgG
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抗体描述
IGF1A-Specific Rabbit Polyclonal antibody. Positive WB detected in mouse testis tissue, L02 cells, mouse liver tissue, mouse ovary tissue, mouse uterus tissue, PC-3 cells. Positive IP detected in mouse liver tissue. Positive IHC detected in human liver tissue, human liver cancer tissue. Positive IF detected in HepG2 cells, HeLa cells. Observed molecular weight by Western-blot: 15-20 kDa
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抗体应用
ELISA, WB, IP, IF, IHC
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应用推荐
Recommended Dilution:
WB: 1:200-1:2000
IP: 1:200-1:1000
IHC: 1:20-1:200
IF: 1:20-1:200
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特异性
Human,Mouse,Rat; other species not tested.
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蛋白别名
IBP1, IGF I, IGF1, IGF1A, IGF1B, IGFI, Insulin like growth factor I, Mechano growth factor, MGF, Somatomedin C
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制备方法
This antibody was obtained by immunization of Peptide. Purification method: Antigen affinity purified.
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组分
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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储存方法
Store at -20℃. DO NOT ALIQUOT
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背景介绍
IGF1, also named as IBP1, MGF, IGF-IA and Somatomedin-C, belongs to the insulin family. IGF1 is structurally and functionally related to insulin but have a much higher growth-promoting activity. Altered expression or mutation of IGF-1 is associated with several human disorders, including type I diabetes and various forms of cancer. Defects in IGF1 are the cause of insulin-like growth factor I deficiency (IGF1 deficiency) which is an autosomal recessive disorder characterized by growth retardation, sensorineural deafness and mental retardation. The antibody is specific to isoform IGF-1A.
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参考文献
- Xu X, Hueckstaedt LK, Ren J. Deficiency of insulin-like growth factor 1 attenuates aging-induced changes in hepatic function: role of autophagy. Journal of hepatology. 59(2):308-17. 2013.
- Tang H, Liao Y, Xu L. Estrogen and insulin-like growth factor 1 synergistically promote the development of lung adenocarcinoma in mice. International journal of cancer. 133(10):2473-82. 2013.
- Hu Y, Liu W, Liu Z, Kuang W, He H. Receptor activator of nuclear factor-kappa ligand, OPG, and IGF-I expression during orthodontically induced inflammatory root resorption in the recombinant human growth hormone-treated rats. The Angle orthodontist. 85(4):562-9. 2015.
- Wen Y, Li J, Tan Y. Angelica Sinensis polysaccharides stimulated UDP-sugar synthase genes through promoting gene expression of IGF-1 and IGF1R in chondrocytes: promoting anti-osteoarthritic activity. PloS one. 9(9):e107024. 2014.
- Yuan L, Zhou C, Lu Y. IFN-γ-mediated IRF1/miR-29b feedback loop suppresses colorectal cancer cell growth and metastasis by repressing IGF1. Cancer letters. 359(1):136-47. 2015.