SH3BP5 antibody

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  • 抗体类型:多克隆
  • 抗体来源:兔
  • 抗体应用:ELISA, WB, IHC
  • 特异性:Human,Mouse,Rat; other species not tested.

产品详情

  • 产品名称
    SH3BP5 antibody
  • 抗体类型
    多克隆
  • 抗体来源
    兔
  • 抗体亚型
    兔IgG
  • 抗体描述
    SH3BP5 Rabbit Polyclonal antibody. Positive WB detected in Raji cells. Positive IHC detected in human ovary tumor tissue. Observed molecular weight by Western-blot: 47kd
  • 抗体应用
    ELISA, WB, IHC
  • 应用推荐

    Recommended Dilution:

    WB: 1:200-1:1000

    IHC: 1:20-1:200

  • 特异性
    Human,Mouse,Rat; other species not tested.
  • 蛋白别名
    SAB, SH3 domain binding protein 5, SH3BP 5, SH3BP5
  • 制备方法
    This antibody was obtained by immunization of SH3BP5 recombinant protein (Accession Number: NM_004844). Purification method: Antigen affinity purified.
  • 组分
    PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
  • 储存方法
    Store at -20℃. DO NOT ALIQUOT
  • 背景介绍
    SH3BP5(SH3 domain-binding protein 5) is also named as SAB. It is previously isolated in a screen for proteins capable of binding to the Src homology 3 (SH3) domain of Bruton's tyrosine kinase (Btk) and could play a role in targeting JNK and Btk to mitochondria and/or mediating cross-talk between the JNK and Btk signalling pathways. It has 2 isoforms produced by alternative splicing with the molecular mass of 50 kDa and 32 kDa. There are two bands of 83 kDa and 70 kDa can be detected in A431 and the larger species may correspond to splice variants of SH3BP5 or SH3BP5 proteins that have undergone post-translational modification(PMID:12167088). In addition, we detecte the band of 32 kDa as the isoform 2 of SH3BP5 and another band of 62 kDa besides the 47 kDa and 80 kDa.
  • 参考文献
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