TRIM33 Polyclonal Antibody

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  • 抗体类型:多克隆
  • 抗体来源:兔
  • 抗体应用:WB
  • 特异性:Human

产品详情

  • 产品名称
    TRIM33 Polyclonal Antibody
  • 抗体类型
    多克隆
  • 抗体来源
    兔
  • 抗体亚型
    兔IgG
  • 抗体描述
    Polyclonal antibody to TRIM33
  • 抗体应用
    WB
  • 应用推荐
    WB 1:200 - 1:2000
  • 特异性
    Human
  • 蛋白别名
    TRIM33, ECTO, PTC7, RFG7, TF1G, TIF1G, TIF1GAMMA, TIFGAMMA, tripartite motif containing 33
  • 制备方法
    Antigen: A synthetic peptide of human TRIM33
  • 组分
    PBS with 0.02% sodium azide, pH7.3.
  • 储存方法
    Store at 4℃. Avoid freeze / thaw cycles.
  • 背景介绍
    Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway. According to PubMed:16751102, does not promote a decrease in the level of endogenous SMAD4. May act as a transcriptional repressor. Inhibits the transcriptional response to TGF-beta/BMP signaling cascade. Plays a role in the control of cell proliferation. Its association with SMAD2 and SMAD3 stimulates erythroid differentiation of hematopoietic stem/progenitor (By similarity). Monoubiquitinates SMAD4 and acts as an inhibitor of SMAD4-dependent TGF-beta/BMP signaling cascade (Monoubiquitination of SMAD4 hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF-beta/BMP signaling cascade).
声明：本公司出售产品只能用于科研目的，不得用于诊断或者治疗！