TRIM33 Polyclonal Antibody
- 抗体类型:多克隆
- 抗体来源:兔
- 抗体应用:WB
- 特异性:Human
产品详情
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产品名称
TRIM33 Polyclonal Antibody
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抗体类型
多克隆
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抗体来源
兔
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抗体亚型
兔IgG
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抗体描述
Polyclonal antibody to TRIM33
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抗体应用
WB
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应用推荐
WB 1:200 - 1:2000
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特异性
Human
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蛋白别名
TRIM33, ECTO, PTC7, RFG7, TF1G, TIF1G, TIF1GAMMA, TIFGAMMA, tripartite motif containing 33
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制备方法
Antigen: A synthetic peptide of human TRIM33
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组分
PBS with 0.02% sodium azide, pH7.3.
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储存方法
Store at 4℃. Avoid freeze / thaw cycles.
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背景介绍
Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway. According to PubMed:16751102, does not promote a decrease in the level of endogenous SMAD4. May act as a transcriptional repressor. Inhibits the transcriptional response to TGF-beta/BMP signaling cascade. Plays a role in the control of cell proliferation. Its association with SMAD2 and SMAD3 stimulates erythroid differentiation of hematopoietic stem/progenitor (By similarity). Monoubiquitinates SMAD4 and acts as an inhibitor of SMAD4-dependent TGF-beta/BMP signaling cascade (Monoubiquitination of SMAD4 hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF-beta/BMP signaling cascade).
声明:本公司出售产品只能用于科研目的,不得用于诊断或者治疗!