- 抗体类型:多克隆
- 抗体来源:兔
- 抗体应用:ELISA, WB
- 特异性:Human,Mouse,Rat; other species not tested.
产品详情
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产品名称
ZNF354A antibody
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抗体类型
多克隆
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抗体来源
兔
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抗体亚型
兔IgG
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抗体描述
ZNF354A Rabbit Polyclonal antibody. Positive WB detected in DU 145 cells. Observed molecular weight by Western-blot: 69 kDa
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抗体应用
ELISA, WB
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应用推荐
Recommended Dilution:
WB: 1:500-1:5000
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特异性
Human,Mouse,Rat; other species not tested.
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蛋白别名
EZNF, HKL1, KID 1, KID1, TCF 17, TCF17, Transcription factor 17, zinc finger protein 354A, Zinc finger protein eZNF, ZNF354A
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制备方法
This antibody was obtained by immunization of ZNF354A recombinant protein (Accession Number: XM_047417644). Purification method: Antigen affinity purified.
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组分
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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储存方法
Store at -20℃. DO NOT ALIQUOT
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背景介绍
ZNF354A, also called EZNF, KID-1 or TCF17, belongs to the Kruppel C2H2-type zinc-finger family of proteins that contain KRAB domains and act as transcriptional regulators. Expressed primarily in the adult kidney, ZNF354A is a transcriptional repressor that plays a role in late renal development and is suppressed after renal ischemia. The N-terminus of ZNF354A contains the KRAB domain which confers transcriptional repressor activity, while the C-terminus contains multiple Cys2His2-zinc fingers. ZNF354A is located in the nucleolus and is thought to specifically influence development of the proximal tubule by shutting off dispensable or inhibitory genes. Reduced ZNF354A expression prevents proper cell differentiation and may, therefore, be implicated in renal carcinoma.