ADI-65534 antibody

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  • 抗体类型:单克隆
  • 抗体来源:
  • 抗体应用:
  • 特异性:

产品详情

  • 产品名称
    ADI-65534 antibody
  • 抗体类型
    单克隆
  • 抗体亚型
    Human IgG
  • 抗体描述
    ADI 65534 an neutralizing antibody against ANDV (New World Hantavirus) and PUUV (Old World Hantavirus)
  • 制备方法
    Recombinant expression and purified from CHO cells.
  • 组分
    Lyophilized, PBS(pH7.2)
  • 储存方法
    Store at -20℃. Avoid freeze / thaw cycles.
  • 背景介绍
    ADI-65534 is an engineered antibody variant derived from the pan-hantavirus protective antibody ADI-42898. It was designed to enhance the potency and cross-clade neutralization of the original antibody, particularly against the highly lethal Andes virus (ANDV). ADI-65534 was developed through affinity maturation of ADI-42898, resulting in improved binding affinity and reduced dissociation at acidic pH, which is crucial for its activity against ANDV. It recognizes a quaternary epitope spanning the Gn and Gc subunits of the hantavirus glycoprotein complex, locking the Gn/Gc heterodimer in its prefusion conformation and preventing membrane fusion, a critical step in viral entry. ADI-65534 maintains the broad-spectrum activity of its parent antibody, ADI-42898, and is effective against both Old World and New World hantaviruses.
  • 参考文献
声明：本公司出售产品只能用于科研目的，不得用于诊断或者治疗！