Monomethyl auristatin E (MMAE) Monoclonal Antibody
- 抗体类型:单克隆
- 抗体来源:
- 抗体应用:ELISA
- 特异性:Chemical
产品详情
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产品名称
Monomethyl auristatin E (MMAE) Monoclonal Antibody
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抗体类型
单克隆
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抗体亚型
Mouse IgG1, κ
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抗体描述
Product has been tested in direct ELISA.
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抗体应用
ELISA
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应用推荐
ELISA: 1:5,000-1:20,000
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特异性
Chemical
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制备方法
MMAE conjugated with KLH. Protein G affinity purified
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组分
PBS(pH7.4), lyophilized. Reconstitution: Adding sterile water, prepare a stock solution of 2.0 mg/ml.
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储存方法
Store at -20℃. Avoid freeze / thaw cycles.
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背景介绍
Auristatins are synthetic analogs of dolastatin 10 (D10), a highly cytotoxic antineoplastic agent employed for cancer chemotherapy, which is derived from a marine species known as Dolabella auricularia. Monomethyl auristatin E (MMAE) and monomethyl auristatin F (MMAF) are identified as the best analogs of dolastatin 10, which bind to microtubules and prevent cell proliferation by inhibiting mitosis. MMAE is one of the most commonly used payloads for developing antibody–drug conjugates (ADC).
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参考文献
- Okeley NM, Miyamoto JB, Zhang X, Sanderson RJ, Benjamin DR, Sievers EL, Senter PD, Alley SC. Intracellular activation of SGN-35, a potent anti-CD30 antibody-drug conjugate. Clin Cancer Res. 2010 Feb 1;16(3):888-97. doi: 10.1158/1078-0432.CCR-09-2069. Epub 2010 Jan 19. Erratum in: Clin Cancer Res. 2011 Aug 15;17(16):5524. PMID: 20086002.
- Buckel L, Savariar EN, Crisp JL, Jones KA, Hicks AM, Scanderbeg DJ, Nguyen QT, Sicklick JK, Lowy AM, Tsien RY, Advani SJ. Tumor radiosensitization by monomethyl auristatin E: mechanism of action and targeted delivery. Cancer Res. 2015 Apr 1;75(7):1376-1387. doi: 10.1158/0008-5472.CAN-14-1931. Epub 2015 Feb 13. PMID: 25681274; PMCID: PMC4458508.
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